Botulinumtoxin als neue Option in der Behandlung der Depression

Suker, Samir; Rohde, Kristina Barbara; Hasler, Gregor (2017). Botulinumtoxin als neue Option in der Behandlung der Depression. Swiss archives of neurology, psychiatry and psychotherapy, 168(1), pp. 20-24. EMH Media 10.4414/sanp.2017.00448

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Despite effective pharmacological and psychotherapeutic treatment ­options for depression, about one third of patients affected by depression prove resistant to therapy. The injection of botulinum toxin A (BTA) into the glabellar muscles of the forehead constitutes a new approach to treating depression. Such treatment exhibits relatively significant effectiveness and demonstrates considerably different properties than conventional ­antidepressants. BTA injections into the glabella are associated with an ­antidepressant effect lasting several months, which sets them apart from other pharmacological antidepressant interventions thus far. The local ­injection of BTA entails no ­expected pharmacological interactions with other medications. Such properties may make BTA injections a potentially cost-effective alternative to standard antidepressant treatments, exhibiting only very few undesirable events. Three randomized, placebo-controlled clinical studies have demonstrated the effectiveness of BTA treatment for patients affected by unipolar depressive disorder. Studies conducted to date display a few ­methodological weaknesses. The sample size in the individual studies ­tended to be small, with blinding methods for BTA treatment being not ideal. Currently, several hypotheses are under discussion concerning the mechanism of action of BTA treatment, namely the information-processing hypothesis, the aesthetic hypothesis, as well as the social hypothesis.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Healthcare Research

UniBE Contributor:

Suker, Samir; Rohde, Kristina Barbara and Hasler, Gregor

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2297-6981

Publisher:

EMH Media

Language:

German

Submitter:

Gregor Hasler

Date Deposited:

23 Feb 2017 16:28

Last Modified:

27 Nov 2017 16:10

Publisher DOI:

10.4414/sanp.2017.00448

BORIS DOI:

10.7892/boris.94059

URI:

https://boris.unibe.ch/id/eprint/94059

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