Mesenchymal stem/stromal cells-a key mediator for regeneration after perinatal morbidity?

Müller, Martin; Wolfs, Tim G A; Schoeberlein, Andreina; Gavilanes, Antonio W D; Surbek, Daniel; Kramer, Boris W (2016). Mesenchymal stem/stromal cells-a key mediator for regeneration after perinatal morbidity? Molecular and cellular pediatrics, 3(1), p. 6. SpringerOpen 10.1186/s40348-016-0034-x

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Perinatal complications in both term- and preterm-born infants are a leading cause of neonatal morbidities and mortality. Infants face different challenges in the neonatal intensive care unit with long-term morbidities such as perinatal brain injury and bronchopulmonary dysplasia being particularly devastating. While advances in perinatal medicine have improved our understanding of the pathogenesis, effective therapies to prevent and/or reduce the severity of these disorders are still lacking. The potential of mesenchymal stem/stromal cell (MSC) therapy has emerged during the last two decades, and an increasing effort is conducted to address brain- and lung-related morbidities in neonates at risk. Various studies support the notion that MSCs have protective effects. MSCs are an easy source and may be readily available after birth in a clinical setting. MSCs' mechanisms of action are diverse, including migration and homing, release of growth factors and immunomodulation, and the potential to replace injured cells. Here, we review the pathophysiology of perinatally acquired brain and lung injuries and focus on MSCs as potential candidates for therapeutic strategies summarizing preclinical and clinical evidence.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pränatale Medizin

UniBE Contributor:

Müller, Martin; Schoeberlein, Andreina and Surbek, Daniel

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2194-7791

Publisher:

SpringerOpen

Language:

English

Submitter:

Monika Zehr

Date Deposited:

26 Apr 2017 08:51

Last Modified:

27 Mar 2019 12:26

Publisher DOI:

10.1186/s40348-016-0034-x

PubMed ID:

26869264

Uncontrolled Keywords:

Bronchopulmonary dysplasia; Hypoxic-ischemic encephalopathy; Mesenchymal stem cells; Neonatal; Perinatal; Perinatal brain injury

BORIS DOI:

10.7892/boris.94154

URI:

https://boris.unibe.ch/id/eprint/94154

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