Homo-DNA templated chemistry and its application to nucleic acid sensing

Stoop, Matthias; Leumann, Christian J. (2011). Homo-DNA templated chemistry and its application to nucleic acid sensing. Chemical communications, 47(26), pp. 7494-7496. Cambridge: Royal Society of Chemistry 10.1039/C1CC11469G

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We have investigated the homo-DNA templated Staudinger reduction of the profluorophore rhodamine azide and have applied this reaction to the detection of natural DNA with a hybrid homo-DNA/DNA molecular beacon. In this system the sensing and the reporting unit are bioorthogonal to each other which facilitates sequence design and increases fidelity.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Stoop, Matthias and Leumann, Christian

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1359-7345

Publisher:

Royal Society of Chemistry

Language:

English

Submitter:

Christian Leumann

Date Deposited:

04 Oct 2013 14:26

Last Modified:

10 Aug 2015 11:20

Publisher DOI:

10.1039/C1CC11469G

Web of Science ID:

000291823400062

BORIS DOI:

10.7892/boris.9417

URI:

https://boris.unibe.ch/id/eprint/9417 (FactScience: 215150)

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