Laparoscopic Indocyanine Green Sentinel Lymph Node Mapping in Endometrial Cancer.

Papadia, Andrea; Imboden, Sara; Siegenthaler, Franziska Anna; Gasparri, Maria Luisa; Mohr, Stefan; Lanz, Susanne; Mueller, Michael (2016). Laparoscopic Indocyanine Green Sentinel Lymph Node Mapping in Endometrial Cancer. Annals of surgical oncology, 23(7), pp. 2206-2211. Springer 10.1245/s10434-016-5090-x

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BACKGROUND In endometrial cancer (EMCA), indocyanine green (ICG) sentinel lymph node (SLN) mapping has been reported, mainly in conjunction with robotic surgery. OBJECTIVE We aimed to evaluate detection rates, sensitivity, and false negative (FN) rate of laparoscopic ICG SLN mapping in EMCA, and to evaluate differences in surgical outcomes between patients subjected to SLN biopsy only versus lymphadenectomy. METHODS A retrospective analysis of EMCA patients undergoing ICG SLN mapping ± pelvic (PLND) and/or para-aortic lymphadenectomy (PALND) was performed. Detection rates were calculated for the entire cohort. Sensitivity and FN rates were calculated for patients undergoing lymphadenectomy after SLN mapping, and surgical outcome was compared among patients undergoing SLN mapping only versus lymphadenectomy. RESULTS Of 75 patients, 33 underwent SLN mapping and 42 underwent SLN mapping followed by PLND/PALND. Overall and bilateral detection rates were 96 % (72/75) and 88 % (66/75), respectively, and the median number of removed SLNs, pelvic non-SLNs (NSLN) and para-aortic NSLNs was 3, 27, and 19, respectively. With a FN rate of 8.3 %, only one patient had bilateral FN SLNs and a metastatic para-aortal NSLN. Estimated blood loss (EBL) and operative (OR) time were significantly lower in patients undergoing SLN mapping only. No differences in complication rates between patients undergoing SLN mapping only and patients undergoing lymphadenectomy were recorded. CONCLUSIONS Laparoscopic ICG SLN mapping has excellent overall and bilateral detection rates and a low FN rate. Compared with lymphadenectomy, SLN biopsy is associated with significantly lower EBL and shorter OR time.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Papadia, Andrea; Imboden, Sara; Siegenthaler, Franziska Anna; Mohr, Stefan; Lanz, Susanne and Mueller, Michael


600 Technology > 610 Medicine & health








Monika Zehr

Date Deposited:

26 Apr 2017 09:53

Last Modified:

26 Apr 2017 09:53

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