Alternative DNA base-pairs: from efforts to expand the genetic code to potential material applications

Wojciechowski, Filip; Leumann, Christian J. (2011). Alternative DNA base-pairs: from efforts to expand the genetic code to potential material applications. Chemical Society reviews, 40(12), pp. 5669-5679. London: Royal Society of Chemistry 10.1039/C1CS15027H

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The complementary Watson-Crick base-pairs, A:T and G:C, have long been recognized as pivotal to both the stability of the DNA double helix and replication/transcription. Recently, the replacement of the Watson-Crick base-pairs with other molecular entities has received considerable attention. In this tutorial review we highlight different approaches used to replace natural base-pairs and equip them with novel function. We also discuss the advantages that non-natural base-pairs convey with respect to practical applications.

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