Alternative DNA base-pairs: from efforts to expand the genetic code to potential material applications

Wojciechowski, Filip; Leumann, Christian J. (2011). Alternative DNA base-pairs: from efforts to expand the genetic code to potential material applications. Chemical Society reviews, 40(12), pp. 5669-5679. London: Royal Society of Chemistry 10.1039/C1CS15027H

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The complementary Watson-Crick base-pairs, A:T and G:C, have long been recognized as pivotal to both the stability of the DNA double helix and replication/transcription. Recently, the replacement of the Watson-Crick base-pairs with other molecular entities has received considerable attention. In this tutorial review we highlight different approaches used to replace natural base-pairs and equip them with novel function. We also discuss the advantages that non-natural base-pairs convey with respect to practical applications.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Wojciechowski, Filip and Leumann, Christian

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0306-0012

Publisher:

Royal Society of Chemistry

Language:

English

Submitter:

Christian Leumann

Date Deposited:

04 Oct 2013 14:26

Last Modified:

10 Aug 2015 11:20

Publisher DOI:

10.1039/C1CS15027H

Web of Science ID:

000296986000005

BORIS DOI:

10.7892/boris.9420

URI:

https://boris.unibe.ch/id/eprint/9420 (FactScience: 215154)

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