A biological perspective on differences and similarities between burnout and depression

Orosz, Ariane; Federspiel, Andrea; Haisch, Sarie; Seeher, Christian; Dierks, Thomas; Cattapan-Ludewig, Katja (2017). A biological perspective on differences and similarities between burnout and depression. Neuroscience & biobehavioral reviews, 73, pp. 112-122. Elsevier 10.1016/j.neubiorev.2016.12.005

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To compare and contrast burnout and depression is not only a conceptual issue, but may deliver important directions for treatment approaches and stabilize the awareness of disease which is essential for affected individuals. Because of the symptomatic overlap, it is a subject of multidimensional research and discussion to find specific signatures to differentiate between the two phenomena or to present evidence that they are different aspects of the same disorder. Both pathologies are regarded as stress-related disorders. Therefore, in this review burnout and depression are discussed on the basis of biological parameters, mainly heart rate variability (HRV) and brain-derived neurotrophic factor (BDNF), which are crucial to the stress response system. It emerges that instead of finding one specific discriminating marker, future research should rather concentrate on elaborating indices for burnout and depression which integrate combinations of parameters found in genetics, neurobiology, physiology and environment.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center

UniBE Contributor:

Orosz, Ariane; Federspiel, Andrea; Dierks, Thomas and Cattapan-Ludewig, Katja

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0149-7634

Publisher:

Elsevier

Language:

English

Submitter:

Ariane Orosz

Date Deposited:

22 Mar 2017 10:38

Last Modified:

01 Sep 2018 02:30

Publisher DOI:

10.1016/j.neubiorev.2016.12.005

PubMed ID:

27993607

Uncontrolled Keywords:

Allostatic load index; Autonomic nervous system; Brain-derived neurotrophic factor; Burnout; Childhood adversity; Depression; Heart rate variability; Hippocampal volume; Parasympathetic nervous system; Stress; Stress-related disorders

BORIS DOI:

10.7892/boris.94210

URI:

https://boris.unibe.ch/id/eprint/94210

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