Interaction of biomedical nanoparticles with the pulmonary immune system.

Blank, Fabian; Fytianos, Kleanthis; Seydoux, Emilie; Rodriguez-Lorenzo, Laura; Petri-Fink, Alke; Von Garnier, Christophe; Rothen-Rutishauser, Barbara (2017). Interaction of biomedical nanoparticles with the pulmonary immune system. Journal of nanobiotechnology, 15(6), p. 6. BioMed Central 10.1186/s12951-016-0242-5

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Engineered nanoparticles (NPs) offer site-specific delivery, deposition and cellular uptake due to their unique physicochemical properties and were shown to modulate immune responses. The respiratory tract with its vast surface area is an attractive target organ for innovative immunomodulatory therapeutic applications by pulmonary administration of such NPs, enabling interactions with resident antigen-presenting cells (APCs), such as dendritic cells and macrophages. Depending on the respiratory tract compartment, e.g. conducting airways, lung parenchyma, or lung draining lymph nodes, APCs extensively vary in their number, morphology, phenotype, and function. Unique characteristics and plasticity render APC populations ideal targets for inhaled specific immunomodulators. Modulation of immune responses may operate in different steps of the immune cell-antigen interaction, i.e. antigen uptake, trafficking, processing, and presentation to T cells. Meticulous analysis of the immunomodulatory potential, as well as pharmacologic and biocompatibility testing of inhalable NPs is required to develop novel strategies for the treatment of respiratory disorders such as allergic asthma. The safe-by-design and characterization of such NPs requires well coordinated interdisciplinary research uniting engineers, chemists biologists and respiratory physicians. In this review we will focus on in vivo data available to facilitate the design of nanocarrier-based strategies using NPs to modulate pulmonary immune responses.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Pneumologie (Erwachsene)
09 Interdisciplinary Units > Microscopy Imaging Center MIC
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Services > Core Facility Live Cell Imaging (LCI)

UniBE Contributor:

Blank, Fabian and Von Garnier, Christophe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1477-3155

Publisher:

BioMed Central

Language:

English

Submitter:

Rahel Holderegger

Date Deposited:

01 Feb 2017 10:07

Last Modified:

19 Feb 2019 14:47

Publisher DOI:

10.1186/s12951-016-0242-5

PubMed ID:

28069025

Uncontrolled Keywords:

Biomedical nanoparticles; Immune-modulation; In vivo models; Pulmonary antigen presenting cells; Specific targeting

BORIS DOI:

10.7892/boris.94225

URI:

https://boris.unibe.ch/id/eprint/94225

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