Mistaking 2C-P for 2C-B: What a Difference a Letter Makes

Stoller, Adrian; Dolder, PC; Bodmer, M; Hammann, F; Rentsch, KM; Exadaktylos, Aristomenis; Liechti, ME; Liakoni, Evangelia (2017). Mistaking 2C-P for 2C-B: What a Difference a Letter Makes. Journal of analytical toxicology, 41(1), pp. 77-79. Oxford University Press 10.1093/jat/bkw108

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2,5-Dimethoxy-4(n)-propylphenethylamine (2C-P) is a synthetic phenethylamine derivative belonging to the large family of the so-called 2C drugs. These compounds can differ significantly in receptor affinity, potency and duration of action, and an important structural difference is the ligand in the 4 position of the phenyl ring, such as propyl in 2C-P or bromine in 2,5-dimethoxy-4-bromophenethylamine (2C-B). The 2C drugs are known for their hallucinogenic properties. We present a case of a 19-year-old male admitted to the emergency department with severe hallucinations, mydriasis, tachycardia, agitation and confusion following the use of a substance sold as 2C-B. By using liquid chromatography–mass spectrometry, the more potent substance 2C-P was detected and quantified. On the basis of two blood sample concentrations, the estimated Elimination half-life was 19 h. This case report illustrates and discusses the differences in potency and duration of action of 2C drugs.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center

UniBE Contributor:

Stoller, Adrian; Exadaktylos, Aristomenis and Liakoni, Evangelia


600 Technology > 610 Medicine & health




Oxford University Press




Evangelia Liakoni

Date Deposited:

10 Feb 2017 13:54

Last Modified:

02 Feb 2018 13:46

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