Characteristics and knowledge synthesis approach for 456 network meta-analyses: a scoping review.

Zarin, Wasifa; Veroniki, Areti Angeliki; Nincic, Vera; Vafaei, Afshin; Reynen, Emily; Motiwala, Sanober S; Antony, Jesmin; Sullivan, Shannon M; Rios, Patricia; Daly, Caitlin; Ewusie, Joycelyne; Petropoulou, Maria; Nikolakopoulou, Adriani; Chaimani, Anna; Salanti, Georgia; Straus, Sharon E; Tricco, Andrea C (2017). Characteristics and knowledge synthesis approach for 456 network meta-analyses: a scoping review. BMC medicine, 15(1), p. 3. BioMed Central 10.1186/s12916-016-0764-6

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BACKGROUND Network meta-analysis (NMA) has become a popular method to compare more than two treatments. This scoping review aimed to explore the characteristics and methodological quality of knowledge synthesis approaches underlying the NMA process. We also aimed to assess the statistical methods applied using the Analysis subdomain of the ISPOR checklist. METHODS Comprehensive literature searches were conducted in MEDLINE, PubMed, EMBASE, and Cochrane Database of Systematic Reviews from inception until April 14, 2015. References of relevant reviews were scanned. Eligible studies compared at least four different interventions from randomised controlled trials with an appropriate NMA approach. Two reviewers independently performed study selection and data abstraction of included articles. All discrepancies between reviewers were resolved by a third reviewer. Data analysis involved quantitative (frequencies) and qualitative (content analysis) methods. Quality was evaluated using the AMSTAR tool for the conduct of knowledge synthesis and the ISPOR tool for statistical analysis. RESULTS After screening 3538 citations and 877 full-text papers, 456 NMAs were included. These were published between 1997 and 2015, with 95% published after 2006. Most were conducted in Europe (51%) or North America (31%), and approximately one-third reported public sources of funding. Overall, 84% searched two or more electronic databases, 62% searched for grey literature, 58% performed duplicate study selection and data abstraction (independently), and 62% assessed risk of bias. Seventy-eight (17%) NMAs relied on previously conducted systematic reviews to obtain studies for inclusion in their NMA. Based on the AMSTAR tool, almost half of the NMAs incorporated quality appraisal results to formulate conclusions, 36% assessed publication bias, and 16% reported the source of funding. Based on the ISPOR tool, half of the NMAs did not report if an assessment for consistency was conducted or whether they accounted for inconsistency when present. Only 13% reported heterogeneity assumptions for the random-effects model. CONCLUSIONS The knowledge synthesis methods and analytical process for NMAs are poorly reported and need improvement.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)

UniBE Contributor:

Nikolakopoulou, Adriani and Salanti, Georgia

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1741-7015

Publisher:

BioMed Central

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

24 Jan 2017 15:11

Last Modified:

26 Jan 2017 10:45

Publisher DOI:

10.1186/s12916-016-0764-6

PubMed ID:

28052774

Uncontrolled Keywords:

AMSTAR; ISPOR; Mixed-treatment; Multiple treatments; Research reporting

BORIS DOI:

10.7892/boris.94322

URI:

https://boris.unibe.ch/id/eprint/94322

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