Copeptin and risk stratification in patients with ischemic stroke and transient ischemic attack: The CoRisk Study

De Marchis, Gian Marco; Katan, Mira; Weck, Anja; Brekenfeld, Caspar; Mattle, Heinrich P; Buhl, Daniela; Müller, Beat; Christ-Crain, Mirjam; Arnold, Marcel (2012). Copeptin and risk stratification in patients with ischemic stroke and transient ischemic attack: The CoRisk Study. International journal of stroke, 8(3), pp. 214-218. Oxford: Blackwell Publishing 10.1111/j.1747-4949.2007.00136.x

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RATIONALE: Copeptin independently predicts functional outcome and mortality at 90 days and one-year after ischemic stroke. In patients with transient ischemic attack, elevated copeptin values indicate an increased risk of further cerebrovascular events. AIMS: The Copeptin Risk Stratification (CoRisk) study aims to validate the predictive value of copeptin in patients with ischemic stroke and transient ischemic attack. In patients with ischemic stroke, the CoRisk study aims to further explore the effect of treatment (i.e. thrombolysis) on the predictive value of copeptin. DESIGN: Prospective observational multicenter study analyzing three groups of patients, i.e. patients with ischemic stroke treated with and without thrombolysis and patients with transient ischemic attack. OUTCOMES: Primary end-point: In patients with ischemic stroke, the primary end-point includes disability (modified Rankin scale from 3 to 5) and mortality (modified Rankin scale 6) at three-months after stroke. In patients with transient ischemic attack, the primary end-point is a recurrent ischemic cerebrovascular event (i.e. ischemic stroke or recurrent transient ischemic attack). Secondary end-point: In patients with ischemic stroke, the secondary end-points include in-house complications (i.e. symptomatic intracerebral hemorrhage, malignant edema, aspiration pneumonia or seizures during hospitalization, and in-house mortality).

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

De Marchis, Gian Marco; Weck, Anja; Mattle, Heinrich and Arnold, Marcel

ISSN:

1747-4930

Publisher:

Blackwell Publishing

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:26

Last Modified:

08 Jun 2016 10:27

Publisher DOI:

10.1111/j.1747-4949.2007.00136.x

PubMed ID:

22336226

Web of Science ID:

000248857700006

URI:

https://boris.unibe.ch/id/eprint/9434 (FactScience: 215171)

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