The Liver at the Nexus of Host-Microbial Interactions.

Macpherson, Andrew; Heikenwalder, Mathias; Ganal-Vonarburg, Stephanie (2016). The Liver at the Nexus of Host-Microbial Interactions. Cell host & microbe, 20(5), pp. 561-571. Elsevier 10.1016/j.chom.2016.10.016

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The liver receives blood from the intestine, from the spleen, and directly from the heart and holds a vital position in vertebrate physiology. It plays a role in intermediary metabolism, bile secretion, maintaining blood sterility, serum homeostasis, xenobiotic detoxification, and immunological activity. This article provides our perspective on the liver as a nexus in establishing and maintaining host microbial mutualism. We discuss the role of the liver not only in sanitizing the blood stream from penetrant live microbes, but also in metabolizing xenobiotics that are synthesized or modified by intestinal microbes, and how microbiota modify the signaling potential of bile acids. The combination of bile acids as hormones and the metabolic control from pervasive effects of other absorbed microbial molecules powerfully shape hepatic metabolism. In addition, intestinal microbial metabolites can be sensed by liver-resident immune cells, which may disturb liver homeostasis, leading to fibrosis and liver cancer.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

UniBE Contributor:

Macpherson, Andrew and Ganal-Vonarburg, Stephanie

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1931-3128

Publisher:

Elsevier

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

03 May 2017 10:12

Last Modified:

08 May 2017 10:12

Publisher DOI:

10.1016/j.chom.2016.10.016

PubMed ID:

27832587

Uncontrolled Keywords:

Kupffer cells; bile acids; carbohydrate metabolism; fat metabolism; fatty liver; liver; liver cancer; liver fibrosis; microbiota; xenobiotics

BORIS DOI:

10.7892/boris.94420

URI:

https://boris.unibe.ch/id/eprint/94420

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