Stimulus-induced, sleep-bound, focal seizures: a case report

Siclari, Francesca; Nobili, Lino; Lo Russo, Giorgio; Moscato, Alessio; Buck, Alfred; Bassetti, Claudio L; Khatami, Ramin (2011). Stimulus-induced, sleep-bound, focal seizures: a case report. Sleep, 34(12), pp. 1727-30. Darien, Ill.: American Academy of Sleep Medicine 10.5665/sleep.1448

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In nocturnal frontal lobe epilepsy (NFLE), seizures occur almost exclusively during NREM sleep. Why precisely these seizures are sleep-bound remains unknown. Studies of patients with nonlesional familial forms of NFLE have suggested the arousal system may play a major role in their pathogenesis. We report the case of a patient with pharmaco-resistant, probably cryptogenic form of non-familial NFLE and strictly sleep-bound seizures that could be elicited by alerting stimuli and were associated with ictal bilateral thalamic and right orbital-insular hyperperfusion on SPECT imaging.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bassetti, Claudio




American Academy of Sleep Medicine




Factscience Import

Date Deposited:

04 Oct 2013 14:26

Last Modified:

17 Mar 2015 21:08

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URI: (FactScience: 215183)

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