Cediranib in ovarian cancer: state of the art and future perspectives.

Ruscito, Ilary; Gasparri, Maria Luisa; Marchetti, Claudia; De Medici, Caterina; Bracchi, Carlotta; Palaia, Innocenza; Imboden, Sara; Mueller, Michael; Papadia, Andrea; Muzii, Ludovico; Panici, Pierluigi Benedetti (2016). Cediranib in ovarian cancer: state of the art and future perspectives. Tumor biology, 37(3), pp. 2833-2839. Springer 10.1007/s13277-015-4781-4

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Despite the dramatic improvements achieved in cancer treatment through a better understanding of the tumor biology, ovarian cancer is still characterized by a poor prognosis: most patients diagnosed with this disease will ultimately die from it. In various clinical trials conducted over a time span of two decades, new combinations of conventional chemotherapy regimens have failed to achieve significant improvements in oncologic outcome in ovarian cancer patients. We have now entered an era of "personalized medicine" in which new medications are designed to specifically target molecular pathways involved in carcinogenesis and cancer progression. Encouraging results in different tumor types have been reported, applying an increasing number of target therapies that are still under evaluation. In this setting, one of the most successfully targeted molecular pathways is tumor angiogenesis. Bevacizumab, a monoclonal antibody binding vascular endothelial growth factor (VEGF), has been recently incorporated in the treatment of primary and recurrent ovarian cancer patients after multiple phase III randomized controlled trials have proven its clinical benefit. Based on these positive results, more anti-angiogenic molecules using different mechanisms of action have been developed and are currently under investigation. Among these molecules, the tyrosine kinases inhibitors are probably the most promising ones. Cediranib is a tyrosine kinase inhibitor targeting VEGF receptors that has been tested in various trials with promising results. The aim of this manuscript is to review the current role of cediranib in the treatment of ovarian cancer and to present an overview of the ongoing clinical trials in this setting.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Imboden, Sara; Mueller, Michael and Papadia, Andrea

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1010-4283

Publisher:

Springer

Language:

English

Submitter:

Monika Zehr

Date Deposited:

10 May 2017 09:26

Last Modified:

16 Jul 2018 14:36

Publisher DOI:

10.1007/s13277-015-4781-4

PubMed ID:

26753963

Uncontrolled Keywords:

Anti-angiogenesis; Cediranib; Ovarian cancer; Target therapy; Tyrosine kinase inhibitors

URI:

https://boris.unibe.ch/id/eprint/94520

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