Association between resistin levels and cardiovascular disease events in older adults: The health, aging and body composition study.

Gencer, Baris; Auer, Reto; de Rekeneire, Nathalie; Butler, Javed; Kalogeropoulos, Andreas; Bauer, Douglas C; Kritchevsky, Stephen B; Miljkovic, Iva; Vittinghoff, Eric; Harris, Tamara; Rodondi, Nicolas (2016). Association between resistin levels and cardiovascular disease events in older adults: The health, aging and body composition study. Atherosclerosis, 245, pp. 181-186. Elsevier 10.1016/j.atherosclerosis.2015.12.004

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OBJECTIVE Prospective data on the association between resistin levels and cardiovascular disease (CVD) events are sparse with conflicting results. METHODS We studied 3044 aged 70-79 years from the Health, Aging, and Body Composition Study. CVD events were defined as coronary heart disease (CHD) or stroke events. «Hard » CHD events were defined as CHD death or myocardial infarction. We estimated hazard ratio (HR) and 95% confidence intervals (CI) according to the quartiles of serum resistin concentrations and adjusted for clinical variables, and then further adjusted for metabolic disease (body mass index, fasting plasma glucose, abdominal visceral and subcutaneous adipose tissue, leptin, adiponectin, insulin) and inflammation (C-reactive protein, interleukin-6, tumor necrosis factors-α). RESULTS During a median follow-up of 10.1 years, 559 patients had « hard » CHD events, 884 CHD events and 1106 CVD Events. Unadjusted incidence rate for CVD events was 36.6 (95% CI 32.1-41.1) per 1000 persons-year in the lowest quartile and 54.0 per 1000 persons-year in the highest quartile (95% CI 48.2-59.8, P for trend < 0.001). In the multivariate models adjusted for clinical variables, HRs for the highest vs. lowest quartile of resistin was 1.52 (95% CI 1.20-1.93, P < 0.001) for « Hard » CHD events, 1.41 (95% CI 1.16-1.70, P = 0.001) for CHD events and 1.35 (95% CI 1.14-1.59, P = 0.002) for CVD events. Further adjustment for metabolic disease slightly reduced the associations while adjustment for inflammation markedly reduced the associations. CONCLUSIONS In older adults, higher resistin levels are associated with CVD events independently of clinical risk factors and metabolic disease markers, but markedly attenuated by inflammation.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)

UniBE Contributor:

Rodondi, Nicolas

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0021-9150

Publisher:

Elsevier

Language:

English

Submitter:

Jacques Donzé

Date Deposited:

10 May 2017 12:52

Last Modified:

12 May 2017 18:52

Publisher DOI:

10.1016/j.atherosclerosis.2015.12.004

PubMed ID:

26724528

Uncontrolled Keywords:

Biomarkers; Cardiovascular prevention; Cohort studies; Inflammation; Insulin resistance

BORIS DOI:

10.7892/boris.94666

URI:

https://boris.unibe.ch/id/eprint/94666

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