Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay

Balistreri, Giuseppe; Bognanni, Claudia; Mühlemann, Oliver (2017). Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay. Viruses, 9(1) Molecular Diversity Preservation International MDPI 10.3390/v9010024

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Nonsense-mediated mRNA decay (NMD), a cellular RNA turnover pathway targeting RNAs with features resulting in aberrant translation termination, has recently been found to restrict the replication of positive-stranded RNA ((+)RNA) viruses. As for every other antiviral immune system, there is also evidence of viruses interfering with and modulating NMD to their own advantage. This review will discuss our current understanding of why and how NMD targets viral RNAs, and elaborate counter-defense strategies viruses utilize to escape NMD.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Bognanni, Claudia and Mühlemann, Oliver

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1999-4915

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Christina Schüpbach

Date Deposited:

08 Feb 2017 10:52

Last Modified:

12 Feb 2017 02:14

Publisher DOI:

10.3390/v9010024

PubMed ID:

28124995

BORIS DOI:

10.7892/boris.94718

URI:

https://boris.unibe.ch/id/eprint/94718

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