Plasmapheresis and immunoadsorption in patients with steroid refractory multiple sclerosis relapses.

Faissner, Simon; Nikolayczik, Johanna; Chan, Andrew; Hellwig, Kerstin; Gold, Ralf; Yoon, Min-Suk; Haghikia, Aiden (2016). Plasmapheresis and immunoadsorption in patients with steroid refractory multiple sclerosis relapses. Journal of neurology, 263(6), pp. 1092-1098. Springer-Medizin-Verlag 10.1007/s00415-016-8105-4

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Patients suffering from multiple sclerosis (MS) are treated with high-dose intravenous steroids during acute relapses. In case of steroid refractory relapses, patients are treated with plasmapheresis or immunoadsorption. Until now data concerning the efficacy of both procedures are scarce. Visual evoked potentials (VEP), visual acuity and degree of remission of deficits caused by a relapse that had led to admission in MS patients (n = 48) treated with PLEX, IA or both in a single university centre setting were evaluated retrospectively. In a grouped analysis of patients treated with combined PLEX/IA, PLEX or IA alone, patients in all groups profited as assessed by VEP. Visual acuity also showed a trend towards a better performance, but lacked significance. In a subgroup analysis only concerning patients with initially pathological VEP there was a significant beneficial effect in the groups treated with PLEX/IA as well as in the group summarizing all patients. The combination of PLEX and IA provides a valid treatment option in steroid-refractory MS-relapses, and IA should be considered in acute relapses especially in patients with side effect of PLEX.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Chan, Andrew

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0340-5354

Publisher:

Springer-Medizin-Verlag

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

03 May 2017 10:24

Last Modified:

03 May 2017 10:24

Publisher DOI:

10.1007/s00415-016-8105-4

PubMed ID:

27039388

Uncontrolled Keywords:

Immunoadsorption; Immunosuppressive treatment; Multiple sclerosis; Plasma exchange

BORIS DOI:

10.7892/boris.94725

URI:

https://boris.unibe.ch/id/eprint/94725

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