LOW ENDOPHTHALMITIS RATES AFTER INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS IN AN OPERATION ROOM: A Retrospective Multicenter Study.

Freiberg, Florentina J; Brynskov, Troels; Munk, Marion; Sørensen, Torben L; Wolf, Sebastian; Wirth, Magdalena A; Becker, Matthias; Michels, Stephan (2017). LOW ENDOPHTHALMITIS RATES AFTER INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS IN AN OPERATION ROOM: A Retrospective Multicenter Study. Retina - the journal of retinal and vitreous diseases, 37(12), pp. 2341-2346. Lippincott, Williams & Wilkins 10.1097/IAE.0000000000001488

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PURPOSE To evaluate the rate of presumed endophthalmitis (EO) after intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections in three European hospitals performed in an operation room (OR) under sterile conditions. METHODS A retrospective multicenter study between 2003 and 2016 at three European sites, City Hospital Triemli Zurich, Switzerland (CHT), Zealand University Hospital Roskilde, Denmark (ZUH) and University Clinic Bern, Switzerland (UCB). Intravitreal injection (IVI) database of each department was reviewed. All anti-vascular endothelial growth factor injections were performed using a standardized sterile technique in an operation room. Injection protocols were similar between the three sites. No preinjection antibiotics were given. Postoperative antibiotics varied among sites. RESULTS A total of 134,701 intravitreal injections were performed at the 3 sites between 2003 and 2016. Ten cases of presumed endophthalmitis were documented: 4 in 50,721 at CHT (95% CI: 0.0071-0.0087%), 2 in 44,666 at ZUH (95% CI: 0.0039-0.0051%), and 4 in 39,314 at UCB (95% CI: 0.0092-0.011%). This results in one case in 13,470 intravitreal injections and a combined incidence of 0.0074% per injection (95% CI: 0.0070-0.0078%). Positive cultures were found in 4 out of 10 presumed endophthalmitis cases. CONCLUSION The standardized sterile technique in an operation room with laminar airflow showed very low rates of endophthalmitis at three European sites.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Munk, Marion and Wolf, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0275-004X

Publisher:

Lippincott, Williams & Wilkins

Language:

English

Submitter:

Sebastian Wolf

Date Deposited:

18 Jul 2017 10:43

Last Modified:

29 Nov 2017 01:30

Publisher DOI:

10.1097/IAE.0000000000001488

PubMed ID:

28099318

BORIS DOI:

10.7892/boris.94760

URI:

https://boris.unibe.ch/id/eprint/94760

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