Jentsch, Holger F R; Buchmann, Andreas; Friedrich, Abel; Eick, Sigrun (2016). Nonsurgical therapy of chronic periodontitis with adjunctive systemic azithromycin or amoxicillin/metronidazole. Clinical oral investigations, 20(7), pp. 1765-1773. Springer 10.1007/s00784-015-1683-1
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OBJECTIVES
The objective of the present study is to compare the effect of systemic adjunctive use of azithromycin with amoxicillin/metronidazole to scaling and root planing (SRP) in a clinical study.
MATERIALS AND METHODS
Data from 60 individuals with chronic periodontitis were evaluated after full-mouth SRP. Antibiotics were given from the first day of SRP, in the test group (n = 29), azithromycin for 3 days and, in the control group (n = 31), amoxicillin/metronidazole for7 days. Probing depth (PD), attachment level (AL), and bleeding on probing (BOP) were recorded at baseline and after 3 and 12 months. Gingival crevicular fluid was analyzed for matrix metalloprotease (MMP)-8 and interleukin (IL)-1beta levels. Subgingival plaque was taken for assessment of the major bacteria associated with periodontitis.
RESULTS
In both groups, PD, AL, and BOP were significantly reduced (p < 0.001). A few significant differences between the groups were found; AL and BOP were significantly better in the test than in the control group at the end of the study (p = 0.020 and 0.009). Periodontopathogens were reduced most in the test group.
CONCLUSIONS
A noninferiority of the treatment with azithromycin in comparison with amoxicillin/metronidazole can be stated. The administration of azithromycin could be an alternative to the use of amoxicillin/metronidazole adjunctive to SRP in patients with moderate or severe chronic periodontitis; however, a randomized placebo-controlled multicenter study is needed.
CLINICAL RELEVANCE
Application of azithromycin as a single antibiotic for 3 days might be considered as an additional adjunctive antibiotic to SRP in selected patients.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Periodontics Research |
UniBE Contributor: |
Eick, Sigrun |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1432-6981 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Eveline Carmen Schuler |
Date Deposited: |
03 May 2017 15:48 |
Last Modified: |
05 Dec 2022 15:02 |
Publisher DOI: |
10.1007/s00784-015-1683-1 |
PubMed ID: |
26685849 |
Uncontrolled Keywords: |
Antibiotics; Chronic periodontitis; Cytokines; Periodontopathogens; Scaling and root planing |
BORIS DOI: |
10.7892/boris.94805 |
URI: |
https://boris.unibe.ch/id/eprint/94805 |