H,K-ATPase type 2 contributes to salt-sensitive hypertension induced by K(+) restriction.

Walter, Christine; Tanfous, Mariem Ben; Igoudjil, Katia; Salhi, Amel; Escher, Geneviève; Crambert, Gilles (2016). H,K-ATPase type 2 contributes to salt-sensitive hypertension induced by K(+) restriction. Pflügers Archiv : European journal of physiology, 468(10), pp. 1673-1683. Springer 10.1007/s00424-016-1872-z

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In industrialized countries, a large part of the population is daily exposed to low K(+) intake, a situation correlated with the development of salt-sensitive hypertension. Among many processes, adaptation to K(+)-restriction involves the stimulation of H,K-ATPase type 2 (HKA2) in the kidney and colon and, in this study, we have investigated whether HKA2 also contributes to the determination of blood pressure (BP). By using wild-type (WT) and HKA2-null mice (HKA2 KO), we showed that after 4 days of K(+) restriction, WT remain normokalemic and normotensive (112 ± 3 mmHg) whereas HKA2 KO mice exhibit hypokalemia and hypotension (104 ± 2 mmHg). The decrease of BP in HKA2 KO is due to the absence of NaCl-cotransporter (NCC) stimulation, leading to renal loss of salt and decreased extracellular volume (by 20 %). These effects are likely related to the renal resistance to vasopressin observed in HKA2 KO that may be explained, in part by the increased production of prostaglandin E2 (PGE2). In WT, the stimulation of NCC induced by K(+)-restriction is responsible for the elevation in BP when salt intake increases, an effect blunted in HKA2-null mice. The presence of an activated HKA2 is therefore required to limit the decrease in plasma [K(+)] but also contributes to the development of salt-sensitive hypertension.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Nephrologie / Hypertonie

UniBE Contributor:

Escher, Geneviève

ISSN:

1432-2013

Publisher:

Springer

Language:

English

Submitter:

Geneviève Escher

Date Deposited:

04 Jun 2018 13:51

Last Modified:

04 Jun 2018 14:00

Publisher DOI:

10.1007/s00424-016-1872-z

PubMed ID:

27562425

Uncontrolled Keywords:

Blood pressure Extracellular volume Low-K+ diet Na+/Cl−-cotransporter Vasopressin

BORIS DOI:

10.7892/boris.94882

URI:

https://boris.unibe.ch/id/eprint/94882

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