Cosgarea, Raluca; Juncar, Raluca; Heumann, Christian; Tristiu, Roxana; Lascu, Liana; Arweiler, Nicole; Stavropoulos, Andreas; Sculean, Anton (2016). Non-surgical periodontal treatment in conjunction with 3 or 7 days systemic administration of amoxicillin and metronidazole in severe chronic periodontitis patients. A placebo-controlled randomized clinical study. Journal of clinical periodontology, 43(9), pp. 767-777. Wiley 10.1111/jcpe.12559
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AIM
To evaluate the effect of 3 or 7 days systemic administration of amoxicillin (AMX) and metronidazole (MET) or placebo as adjunct to non-surgical periodontal treatment in severe chronic periodontitis patients.
METHODS
One hundred and two patients with severe chronic periodontitis [e.g. ≥1 site with probing pocket depth (PD) ≥ 6 mm per quadrant] were randomly divided into three equally sized groups and treated with either scaling and root planing within 24 h (SRP) + placebo (Group A) or SRP + AMX + MET (both 500 mg × 3 times daily) for 3 days (Group B) or SRP + AMX + MET (both 500 mg × 3 times daily) for 7 days (Group C). PD, clinical attachment level (CAL), bleeding on probing (BOP), full-mouth plaque scores (FMPS) and gingival bleeding index (GBI) were assessed prior to treatment (baseline), and at 3 and 6 months post-treatment. The primary outcome variable was the difference (Δ) in the number of sites with PD ≥ 6 mm.
RESULTS
Ninety-one patients completed the study. At both 3 and 6 months, all three treatment protocols resulted in statistically significant improvements compared to baseline for all evaluated clinical parameters (p < 0.001). At 6 months, a statistically significantly greater reduction in the mean number of sites with PD ≥ 6 mm was observed in group B (28.62 ± 15.32 sites) and group C (30.45 ± 15.04 sites) compared to the placebo group (17.10 ± 14.68 sites). Furthermore, both the 3- and the 7-day antibiotic regimen resulted in statistically significantly higher clinical improvements compared to the placebo group (p < 0.05).
CONCLUSION
The present findings indicate that in patients with severe chronic periodontitis, non-surgical periodontal therapy in conjunction with a 3 or 7 days systemic administration of AMX + MET may lead to significantly greater clinical improvements compared to non-surgical therapy alone.
Item Type: |
Journal Article (Original Article) |
---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology 04 Faculty of Medicine > School of Dental Medicine |
UniBE Contributor: |
Sculean, Anton |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0303-6979 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Eveline Carmen Schuler |
Date Deposited: |
08 May 2017 08:09 |
Last Modified: |
05 Dec 2022 15:02 |
Publisher DOI: |
10.1111/jcpe.12559 |
PubMed ID: |
27027501 |
Uncontrolled Keywords: |
amoxicillin, metronidazole, non-surgical, periodontal, Treatment, systemic, antibiotics |
BORIS DOI: |
10.7892/boris.94925 |
URI: |
https://boris.unibe.ch/id/eprint/94925 |