Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials.

Mills, Charlotte E; Flury, Andreas; Marmet, Cynthia; Poquet, Laura; Rimoldi, Stefano; Sartori, Claudio; Rexhaj, Emrush; Brenner, Roman; Allemann, Yves; Zimmermann, Diane; Gibson, Glenn R; Mottram, Don S; Oruna-Concha, Maria-Jose; Actis-Goretta, Lucas; Spencer, Jeremy P E (2017). Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. Clinical nutrition, 36(6), pp. 1520-1529. Elsevier 10.1016/j.clnu.2016.11.013

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BACKGROUND & AIMS Polyphenol intake has been linked to improvements in human vascular function, although data on hydroxycinnamates, such as chlorogenic acid (CGA) have not yet been studied. We aimed to investigate the impact of coffee intake rich in chlorogenic acid on human vascular function and whether CGAs are involved in potential effects. METHODS Two acute randomized, controlled, cross-over human intervention trials were conducted. The impact of coffee intake, matched for caffeine but differing in CGA content (89, and 310 mg) on flow-mediated dilatation (FMD) was assessed in 15 healthy male subjects. In a second intervention trial conducted with 24 healthy male subjects, the impact of pure 5-caffeoylquinic acid (5-CQA), the main CGA in coffee (5-CQA; 450 mg and 900 mg) on FMD was also investigated. RESULTS We observed a bi-phasic FMD response after low and high polyphenol, (89 mg and 310 mg CGA) intake, with increases at 1 (1.10 ± 0.43% and 1.34 ± 0.62%, respectively) and 5 (0.79% ± 0.32 and 1.52% ± 0.40, respectively) hours post coffee consumption. FMD responses to coffee intake was closely paralleled by the appearance of CGA metabolites in plasma, notably 3-, 4- and 5-feruloylquinic acid and ferulic-4'-O-sulfate at 1 h and isoferulic-3'-O-glucuronide and ferulic-4'-O-sulfate at 5 h. Intervention with purified 5-CQA (450 mg) also led to an improvement in FMD response relative to control (0.75 ± 1.31% at 1 h post intervention, p = 0.06) and concomitant appearance of plasma metabolites. CONCLUSIONS Coffee intake acutely improves human vascular function, an effect, in part, mediated by 5-CQA and its physiological metabolites. STUDY REGISTRATION The National Institutes of Health (NIH) on ClinicalTrials.govNCT01813981 and NCT01772784.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie

UniBE Contributor:

Rimoldi, Stefano

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0261-5614

Publisher:

Elsevier

Language:

English

Submitter:

Stefano Rimoldi

Date Deposited:

18 Apr 2017 13:48

Last Modified:

09 Nov 2017 01:30

Publisher DOI:

10.1016/j.clnu.2016.11.013

PubMed ID:

28012692

Uncontrolled Keywords:

Chlorogenic acid; Coffee; Flow mediated dilatation (FMD); Phenolics; Vascular

BORIS DOI:

10.7892/boris.95024

URI:

https://boris.unibe.ch/id/eprint/95024

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