Effects of perinatal, late foetal, and early embryonic insults on the cardiovascular phenotype in experimental animal models and humans.

Meister, Theo Arthur; Rexhaj, Emrush; Rimoldi, Stefano; Scherrer, Urs; Sartori, Claudio (2016). Effects of perinatal, late foetal, and early embryonic insults on the cardiovascular phenotype in experimental animal models and humans. Vasa - European journal of vascular medicine, 45(6), pp. 439-449. Huber 10.1024/0301-1526/a000573

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Cardiovascular diseases are the main cause of mortality and morbidity in Western countries, but the underlying mechanisms are still poorly understood. Genetic polymorphisms, once thought to represent a major determinant of cardiovascular risk, individually and collectively, only explain a tiny fraction of phenotypic variation and disease risk in humans. It is now clear that non-genetic factors, i.e., factors that modify gene activity without changing the DNA sequence and that are sensitive to the environment can cause important alterations of the cardiovascular phenotype in experimental animal models and humans. Here, we will review recent studies demonstrating that distinct pathological events during the perinatal (transient perinatal hypoxemia), late foetal (preeclampsia), and early embryonic (assisted reproductive technologies) periods induce profound alterations of the cardiovascular phenotype in humans and experimental animals. Moreover, we will provide evidence that epigenetic modifications are contributing importantly to this problem and are conferring the potential for its transmission to subsequent generations.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie

UniBE Contributor:

Rimoldi, Stefano

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0301-1526

Publisher:

Huber

Language:

English

Submitter:

Stefano Rimoldi

Date Deposited:

18 Apr 2017 14:12

Last Modified:

18 Apr 2017 14:12

Publisher DOI:

10.1024/0301-1526/a000573

PubMed ID:

27598052

Uncontrolled Keywords:

ART; Cardiovascular risk; epigenetic; foetal programming; preeclampsia; vascular dysfunction

BORIS DOI:

10.7892/boris.95027

URI:

https://boris.unibe.ch/id/eprint/95027

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