Novel Insights into Cardiovascular Regulation in Patients with Chronic Mountain Sickness.

Rimoldi, Stefano; Rexhaj, Emrush; Villena, Mercedes; Salmon, Carlos Salinas; Allemann, Yves; Scherrer, Urs; Sartori, Claudio (2016). Novel Insights into Cardiovascular Regulation in Patients with Chronic Mountain Sickness. In: Hypoxia Translation in Progress. Advances in Experimental Medicine and Biology: Vol. 903 (pp. 83-100). Springer 10.1007/978-1-4899-7678-9_6

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Studies of high-altitude populations, and in particular of maladapted subgroups, may provide important insight into underlying mechanisms involved in the pathogenesis of hypoxemia-related disease in general. Chronic mountain sickness (CMS) is a major public health problem in mountainous regions of the world affecting many millions of high-altitude dwellers. It is characterized by exaggerated chronic hypoxemia, erythrocytosis, and mild pulmonary hypertension. In later stages these patients often present with right heart failure and are predisposed to systemic cardiovascular disease, but the underlying mechanisms are poorly understood. Here, we present recent new data providing insight into underlying mechanisms that may cause these complications.

Item Type:

Book Section (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie

UniBE Contributor:

Rimoldi, Stefano

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0065-2598

ISBN:

978-1-4899-7676-5

Series:

Advances in Experimental Medicine and Biology

Publisher:

Springer

Language:

English

Submitter:

Stefano Rimoldi

Date Deposited:

28 Mar 2017 11:34

Last Modified:

28 Mar 2017 11:34

Publisher DOI:

10.1007/978-1-4899-7678-9_6

PubMed ID:

27343090

Uncontrolled Keywords:

Arterial stiffness; Chronic hypoxemia; Endothelial function; Intima-media thickness; Nitric oxide; Oxidative stress

URI:

https://boris.unibe.ch/id/eprint/95033

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