Epigenetics in Cardiovascular Regulation.

Sartori, Claudio; Rimoldi, Stefano; Rexhaj, Emrush; Allemann, Yves; Scherrer, Urs (2016). Epigenetics in Cardiovascular Regulation. In: Roach, Robert C.; Hackett, Peter H.; Wagner, Peter D. (eds.) Hypoxia Translation in Progress. Advances in Experimental Medicine and Biology: Vol. 903 (pp. 55-62). Springer 10.1007/978-1-4899-7678-9_4

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Epidemiological studies have shown an association between pathologic events occurring during early life and the development of cardiovascular and metabolic disease in adulthood. These observations have led to the so-called fetal programming of adult disease hypothesis. In line with this hypothesis, short-term exposure to hypoxia after birth predisposes to exaggerated hypoxic pulmonary vasoconstriction later in life in rats, and transient perinatal hypoxia predisposes to exaggerated pulmonary hypertension during short-term exposure to high altitude in humans. Along the same lines, in recent studies in Bolivian high-altitude dwellers, we found that preeclampsia predisposes the offspring to pulmonary and systemic endothelial dysfunction possibly related to impaired NO bioavailability and augmented oxidative stress. Very recent data from our lab suggest that assisted reproductive technologies may represent another important example consistent with this hypothesis. The mechanisms underpinning the developmental origin of this vascular dysfunction are poorly understood. Increasing evidence suggests that epigenetic alterations, such as DNA methylation or histone acetylation may play a role.

Item Type:	Book Section (Review Article)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie
UniBE Contributor:	Rimoldi, Stefano
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0065-2598
ISBN:	978-1-4899-7676-5
Series:	Advances in Experimental Medicine and Biology
Publisher:	Springer
Language:	English
Submitter:	Stefano Rimoldi
Date Deposited:	28 Mar 2017 11:27
Last Modified:	05 Dec 2022 15:02
Publisher DOI:	10.1007/978-1-4899-7678-9_4
PubMed ID:	27343088
Uncontrolled Keywords:	Endothelial function; Epigenetic; Hypoxia; Preeclampsia; Pulmonary hypertension
URI:	https://boris.unibe.ch/id/eprint/95034