Developmental Origins of Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction: Evidence from Humans.

Sartori, Claudio; Rimoldi, Stefano; Duplain, Hervé; Stuber, Thomas; Garcin, Sophie; Rexhaj, Emrush; Allemann, Yves; Scherrer, Urs (2016). Developmental Origins of Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction: Evidence from Humans. Advances in experimental medicine and biology, 903, pp. 17-28. Springer 10.1007/978-1-4899-7678-9_2

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Epidemiological studies have shown an association between pathologic events occurring during fetal/perinatal life and the development of cardiovascular and metabolic disease in adulthood. These observations have led to the so-called developmental origin of adult disease hypothesis. More recently, evidence has been provided that the pulmonary circulation is also an important target for the developmental programming of adult disease in both experimental animal models and in humans. Here we will review this evidence and provide insight into mechanisms that may play a pathogenic role.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie

UniBE Contributor:

Rimoldi, Stefano

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0065-2598

Publisher:

Springer

Language:

English

Submitter:

Stefano Rimoldi

Date Deposited:

17 May 2017 15:55

Last Modified:

17 May 2017 15:55

Publisher DOI:

10.1007/978-1-4899-7678-9_2

PubMed ID:

27343086

Uncontrolled Keywords:

Barker hypothesis; Epigenetics; Perinatal insult

URI:

https://boris.unibe.ch/id/eprint/95035

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