Developmental Origins of Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction: Evidence from Humans.

Sartori, Claudio; Rimoldi, Stefano; Duplain, Hervé; Stuber, Thomas; Garcin, Sophie; Rexhaj, Emrush; Allemann, Yves; Scherrer, Urs (2016). Developmental Origins of Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction: Evidence from Humans. Advances in experimental medicine and biology, 903, pp. 17-28. Springer 10.1007/978-1-4899-7678-9_2

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Epidemiological studies have shown an association between pathologic events occurring during fetal/perinatal life and the development of cardiovascular and metabolic disease in adulthood. These observations have led to the so-called developmental origin of adult disease hypothesis. More recently, evidence has been provided that the pulmonary circulation is also an important target for the developmental programming of adult disease in both experimental animal models and in humans. Here we will review this evidence and provide insight into mechanisms that may play a pathogenic role.

Item Type:	Journal Article (Review Article)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie
UniBE Contributor:	Rimoldi, Stefano
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0065-2598
Publisher:	Springer
Language:	English
Submitter:	Stefano Rimoldi
Date Deposited:	17 May 2017 15:55
Last Modified:	05 Dec 2022 15:02
Publisher DOI:	10.1007/978-1-4899-7678-9_2
PubMed ID:	27343086
Uncontrolled Keywords:	Barker hypothesis; Epigenetics; Perinatal insult
URI:	https://boris.unibe.ch/id/eprint/95035