Felder, Susan; Braun, Nina; Stanga, Zeno; Kulkarni, Prasad; Faessler, Lukas; Kutz, Alexander; Steiner, Deborah; Laukemann, Svenja; Haubitz, Sebastian; Huber, Andreas; Mueller, Beat; Schuetz, Philipp (2016). Unraveling the Link between Malnutrition and Adverse Clinical Outcomes: Association of Acute and Chronic Malnutrition Measures with Blood Biomarkers from Different Pathophysiological States. Annals of nutrition & metabolism, 68(3), pp. 164-172. Karger 10.1159/000444096
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BACKGROUND AND AIMS
Malnutrition is associated with poor clinical outcomes. Whether there is a causal relationship or it merely mirrors a severe patient condition remains unclear. We examined the association of malnutrition with biomarkers characteristic of different pathophysiological states to better understand the underlying etiological mechanisms.
METHODS
We prospectively followed consecutive adult medical inpatients. Multivariable regression models were used to investigate the associations between malnutrition - as assessed using the Nutritional Risk Screening (NRS 2002) - and biomarkers linked to inflammation, stress, renal dysfunction, nutritional status and hematologic function.
RESULTS
A total of 529 patients were included. In a fully adjusted model, malnutrition was significantly associated with the inflammatory markers procalcitonin (0.20, 95% CI 0.03-0.37), proadrenomedullin (0.28, 95% CI 0.12-0.43) and albumin (-0.39, 95% CI -0.57 to -0.21), the stress marker copeptin (0.34, 95% CI 0.17-0.51), the renal function marker urea (0.23, 95% CI 0.07-0.38), the nutritional markers vitamin D25 (-0.22, 95% CI -0.41 to -0.02) and corrected calcium (0.29, 95% CI 0.10-0.49) and the hematological markers hemoglobin (-0.27, 95% CI -0.43 to -0.10) and red blood cell distribution width (0.26, 95% CI 0.07-0.44). Subgroup analysis suggested that acute malnutrition rather than chronic malnutrition was associated with elevated biomarker levels.
CONCLUSION
Acute malnutrition was associated with a pronounced inflammatory response and an alteration in biomarkers associated with different pathophysiological states. Interventional trials are needed to prove causality.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition |
UniBE Contributor: |
Stanga, Zeno |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1421-9697 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Lia Bally |
Date Deposited: |
17 May 2017 09:34 |
Last Modified: |
02 Mar 2023 23:28 |
Publisher DOI: |
10.1159/000444096 |
PubMed ID: |
26855046 |
BORIS DOI: |
10.7892/boris.95086 |
URI: |
https://boris.unibe.ch/id/eprint/95086 |
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