Nakahara, Ken; Haga-Tsujimura, Maiko; Sawada, Kosaku; Mottini, Matthias; Schaller, Benoît; Saulacic, Nikola (2017). Effects of collagen membrane application and cortical bone perforation on de novo bone formation in periosteal distraction: an experimental study in a rabbit calvaria. Oral surgery, oral medicine, oral pathology and oral radiology, 123(2), pp. 173-182. Elsevier 10.1016/j.oooo.2016.09.012
![[img]](https://boris.unibe.ch/style/images/fileicons/text.png) |
Text
1-s2.0-S2212440316303819-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (3MB) |
OBJECTIVES:
The aim of the present study was to assess the impact of collagen membrane application and cortical bone perforations in periosteal distraction osteogenesis.
STUDY DESIGN:
A total of 32 New Zealand rabbits were randomized into four experimental groups, considering two treatment modalities. Calvarial bone was perforated or left intact (P+/-). In half the animals, the distraction mesh was covered with a collagen membrane (M+/-). All animals were subjected to a 7-day latency period and a 10-day distraction period. The samples were harvested after 4-week and 8-week consolidation periods and analyzed histologically and by means of micro-computed tomography.
RESULTS:
Primary, woven bone observed at the 4-week consolidation period was gradually replaced by lamellar bone at the 8-week consolidation period. Significant increase in bone volume was found in all groups (P < .001) and in bone mineral density in groups I (P-/M-; P < .001), III (P+/M-; P < .001), and IV (P+/M+; P = .013). Group III (P+/M-) showed significantly more new bone at the 8-week consolidation period compared with the other three groups (P = .001), with no differences observed in bone mineral density between groups at a given time-point.
CONCLUSIONS:
In the present model, cortical bone perforations have more impact on the osteogenic process compared with the application of a collagen membrane.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Schädel-, Kiefer- und Gesichtschirurgie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Schädel-, Kiefer- und Gesichtschirurgie 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery |
UniBE Contributor: |
Nakahara, Ken, Haga-Tsujimura, Maiko, Sawada, Kosaku, Mottini, Matthias, Schaller, Benoît, Saulacic, Nikola |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2212-4411 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Caroline Dominique Zürcher |
Date Deposited: |
13 Jun 2017 10:25 |
Last Modified: |
05 Dec 2022 15:02 |
Publisher DOI: |
10.1016/j.oooo.2016.09.012 |
PubMed ID: |
27876575 |
BORIS DOI: |
10.7892/boris.95123 |
URI: |
https://boris.unibe.ch/id/eprint/95123 |
Actions (login required)
 |
Edit item |