Effects of collagen membrane application and cortical bone perforation on de novo bone formation in periosteal distraction: an experimental study in a rabbit calvaria

Nakahara, Ken; Haga-Tsujimura, Maiko; Sawada, Kosaku; Mottini, Matthias; Schaller, Benoît; Saulacic, Nikola (2017). Effects of collagen membrane application and cortical bone perforation on de novo bone formation in periosteal distraction: an experimental study in a rabbit calvaria. Oral surgery, oral medicine, oral pathology and oral radiology, 123(2), pp. 173-182. Elsevier 10.1016/j.oooo.2016.09.012

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OBJECTIVES: The aim of the present study was to assess the impact of collagen membrane application and cortical bone perforations in periosteal distraction osteogenesis. STUDY DESIGN: A total of 32 New Zealand rabbits were randomized into four experimental groups, considering two treatment modalities. Calvarial bone was perforated or left intact (P+/-). In half the animals, the distraction mesh was covered with a collagen membrane (M+/-). All animals were subjected to a 7-day latency period and a 10-day distraction period. The samples were harvested after 4-week and 8-week consolidation periods and analyzed histologically and by means of micro-computed tomography. RESULTS: Primary, woven bone observed at the 4-week consolidation period was gradually replaced by lamellar bone at the 8-week consolidation period. Significant increase in bone volume was found in all groups (P < .001) and in bone mineral density in groups I (P-/M-; P < .001), III (P+/M-; P < .001), and IV (P+/M+; P = .013). Group III (P+/M-) showed significantly more new bone at the 8-week consolidation period compared with the other three groups (P = .001), with no differences observed in bone mineral density between groups at a given time-point. CONCLUSIONS: In the present model, cortical bone perforations have more impact on the osteogenic process compared with the application of a collagen membrane.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Schädel-, Kiefer- und Gesichtschirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Schädel-, Kiefer- und Gesichtschirurgie

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery

UniBE Contributor:

Nakahara, Ken; Haga-Tsujimura, Maiko; Sawada, Kosaku; Mottini, Matthias; Schaller, Benoît and Saulacic, Nikola

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2212-4411

Publisher:

Elsevier

Language:

English

Submitter:

Caroline Dominique Zürcher

Date Deposited:

13 Jun 2017 10:25

Last Modified:

05 Feb 2018 16:54

Publisher DOI:

10.1016/j.oooo.2016.09.012

PubMed ID:

27876575

BORIS DOI:

10.7892/boris.95123

URI:

https://boris.unibe.ch/id/eprint/95123

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