Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis.

Martin, Roland; Sospedra, Mireia; Rosito, Maria; Engelhardt, Britta (2016). Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis. European journal of immunology, 46(9), pp. 2078-2090. Wiley-VCH 10.1002/eji.201646485

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Multiple sclerosis (MS) is the most common inflammatory disorder of the central nervous system (CNS) in young adults. When MS is not treated, it leads to irreversible and severe disability. The etiology of MS and its pathogenesis are not fully understood. The recent discovery that MS-associated genetic variants code for molecules related to the function of specific immune cell subsets is consistent with the concept of MS as a prototypic, T-cell-mediated autoimmune disease targeting the CNS. While the therapeutic efficacy of the currently available immunomodulatory therapies further strengthen this concept, differences observed in responses to MS treatment as well as additional clinical and imaging observations have also shown that the autoimmune pathogenesis underlying MS is much more complex than previously thought. There is therefore an unmet need for continued detailed phenotypic and functional analysis of disease-relevant adaptive immune cells and tissues directly derived from MS patients to unravel the immune etiology of MS in its entire complexity. In this review, we will discuss the currently available MS treatment options and approved drugs, including how they have contributed to the understanding of the immune pathology of this autoimmune disease.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Rosito, Maria and Engelhardt, Britta

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0014-2980

Publisher:

Wiley-VCH

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

22 May 2017 11:59

Last Modified:

22 May 2017 12:03

Publisher DOI:

10.1002/eji.201646485

PubMed ID:

27467894

Uncontrolled Keywords:

Autoantibodies; Autoimmune pathogenesis; Autoimmunity; Autoreactive B cells; Autoreactive T cells; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Treatment

BORIS DOI:

10.7892/boris.95358

URI:

https://boris.unibe.ch/id/eprint/95358

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