A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins.

Strauss, Christian; Hu, Yanmin; Coates, Anthony; Perreten, Vincent (2017). A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins. Antimicrobial agents and chemotherapy, 61(1) American Society for Microbiology 10.1128/AAC.01655-16

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A novel erm(44) gene variant, erm(44)v, has been identified by whole-genome sequencing in a Staphylococcus saprophyticus isolate from the skin of a healthy person. It has the particularity to confer resistance to macrolides and lincosamides but not to streptogramin B when expressed in S. aureus The erm(44)v gene resides on a 19,400-bp genomic island which contains phage-associated proteins and is integrated into the chromosome of S. saprophyticus.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology > Molecular Bacterial Epidemiology and Infectiology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Strauss, Christian and Perreten, Vincent

Subjects:

600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Vincent Perreten

Date Deposited:

24 Jul 2017 14:20

Last Modified:

24 Jul 2017 14:20

Publisher DOI:

10.1128/AAC.01655-16

PubMed ID:

27799208

Uncontrolled Keywords:

23S RNA methylase; MLSB; Staphylococcus; antibiotic resistance; coagulase-negative staphylococci; macrolides-lincosamides-streptogramin B; phages

BORIS DOI:

10.7892/boris.95364

URI:

https://boris.unibe.ch/id/eprint/95364

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