WNK1 kinase balances T cell adhesion versus migration in vivo.

Köchl, Robert; Thelen, Flavian; Vanes, Lesley; Brazão, Tiago F; Fountain, Kathryn; Xie, Jian; Huang, Chou-Long; Lyck, Ruth; Stein, Jens Volker; Tybulewicz, Victor L J (2016). WNK1 kinase balances T cell adhesion versus migration in vivo. Nature immunology, 17(9), pp. 1075-1083. Nature Publishing Group 10.1038/ni.3495

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Adhesion and migration of T cells are controlled by chemokines and by adhesion molecules, especially integrins, and have critical roles in the normal physiological function of T lymphocytes. Using an RNA-mediated interference screen, we identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration. We found that WNK1 is a negative regulator of integrin-mediated adhesion, whereas it acts as a positive regulator of migration via the kinases OXSR1 and STK39 and the ion co-transporter SLC12A2. WNK1-deficient T cells home less efficiently to lymphoid organs and migrate more slowly through them. Our results reveal that a pathway previously known only to regulate salt homeostasis in the kidney functions to balance T cell adhesion and migration.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Thelen, Flavian; Lyck, Ruth and Stein, Jens Volker

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1529-2908

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

22 May 2017 14:03

Last Modified:

27 Feb 2018 12:12

Publisher DOI:

10.1038/ni.3495

Related URLs:

PubMed ID:

27400149

BORIS DOI:

10.7892/boris.95389

URI:

https://boris.unibe.ch/id/eprint/95389

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