CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense.

Carevic, M; Öz, H; Fuchs, K; Laval, J; Schroth, C; Frey, N; Hector, A; Bilich, T; Haug, M; Schmidt, A; Autenrieth, S E; Bucher, K; Beer-Hammer, S; Gaggar, A; Kneilling, M; Benarafa, Charaf; Gao, J L; Murphy, P M; Schwarz, S; Moepps, B; ... (2016). CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense. Journal of innate immunity, 8(4), pp. 362-373. Karger 10.1159/000444125

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Pseudomonas aeruginosa is a key opportunistic pathogen causing disease in cystic fibrosis (CF) and other lung diseases such as chronic obstructive pulmonary disease (COPD). However, the pulmonary host defense mechanisms regulating anti-P. aeruginosa immunity remain incompletely understood. Here we demonstrate, by studying an airway P. aeruginosa infection model, in vivo bioluminescence imaging, neutrophil effector responses and human airway samples, that the chemokine receptor CXCR1 regulates pulmonary host defense against P. aeruginosa. Mechanistically, CXCR1 regulates anti-Pseudomonas neutrophil responses through modulation of reactive oxygen species and interference with Toll-like receptor 5 expression. These studies define CXCR1 as a novel, noncanonical chemokine receptor that regulates pulmonary anti-Pseudomonas host defense with broad implications for CF, COPD and other infectious lung diseases.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Benarafa, Charaf

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1662-8128

Publisher:

Karger

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

22 May 2017 15:25

Last Modified:

01 Jul 2017 02:33

Publisher DOI:

10.1159/000444125

PubMed ID:

26950764

BORIS DOI:

10.7892/boris.95412

URI:

https://boris.unibe.ch/id/eprint/95412

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