Basic Rules of T Cell Migration

Stein, Jens Volker; Moalli, Federica; Ackerknecht, Markus (2016). Basic Rules of T Cell Migration. In: Donnadieu, Emmanuel (ed.) Defects in T cell Trafficking and Resistance to Cancer Immunotherapy. Resistance to Targeted Anti-Cancer Therapeutics: Vol. 9 (pp. 1-19). Springer 10.1007/978-3-319-42223-7_1

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The positive correlation of lymphocyte infiltration into solid tumors with the patient survival, as well as recent successes of checkpoint inhibitors enhancing antitumor responses, have kindled a huge interest in cancer immunotherapy. In fact, adoptive cell therapy (ACT) of tumor-recognizing T cells has led to complete recession of tumors in a subset of melanoma patients. Yet, the molecular mechanisms that guide T cells to infiltrate tumor tissue for the detection and destruction of cancer cells are only incompletely understood. Here, we will give an overview on the basic rules of T cell migration, focusing on extra- and intracellular guidance cues gained primarily from intravital two photon imaging, and relate this with the efficient unfolding of adaptive immune responses. From this, we outline the challenges that T cells face entering and maneuvering inside non-lymphoid tissues including tumor sites.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Stein, Jens Volker; Moalli, Federica and Ackerknecht, Markus

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2196-5501

ISBN:

978-3-319-42221-3

Series:

Resistance to Targeted Anti-Cancer Therapeutics

Publisher:

Springer

Language:

English

Submitter:

Ursula Zingg-Zünd

Date Deposited:

28 Mar 2017 11:09

Last Modified:

28 Mar 2017 11:09

Publisher DOI:

10.1007/978-3-319-42223-7_1

Uncontrolled Keywords:

T cell trafficking; Integrins; Small GTPases; Intravital imaging; Extracellular matrix; Guanine exchange factors

URI:

https://boris.unibe.ch/id/eprint/95413

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