Stein, Jens Volker; Moalli, Federica; Ackerknecht, Markus (2016). Basic Rules of T Cell Migration. In: Donnadieu, Emmanuel (ed.) Defects in T cell Trafficking and Resistance to Cancer Immunotherapy. Resistance to Targeted Anti-Cancer Therapeutics: Vol. 9 (pp. 1-19). Springer 10.1007/978-3-319-42223-7_1
Full text not available from this repository.The positive correlation of lymphocyte infiltration into solid tumors with the patient survival, as well as recent successes of checkpoint inhibitors enhancing antitumor responses, have kindled a huge interest in cancer immunotherapy. In fact, adoptive cell therapy (ACT) of tumor-recognizing T cells has led to complete recession of tumors in a subset of melanoma patients. Yet, the molecular mechanisms that guide T cells to infiltrate tumor tissue for the detection and destruction of cancer cells are only incompletely understood. Here, we will give an overview on the basic rules of T cell migration, focusing on extra- and intracellular guidance cues gained primarily from intravital two photon imaging, and relate this with the efficient unfolding of adaptive immune responses. From this, we outline the challenges that T cells face entering and maneuvering inside non-lymphoid tissues including tumor sites.
Item Type: |
Book Section (Book Chapter) |
---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute |
UniBE Contributor: |
Stein, Jens Volker, Moalli, Federica, Ackerknecht, Markus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2196-5501 |
ISBN: |
978-3-319-42221-3 |
Series: |
Resistance to Targeted Anti-Cancer Therapeutics |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Ursula Zingg-Zünd |
Date Deposited: |
28 Mar 2017 11:09 |
Last Modified: |
05 Dec 2022 15:02 |
Publisher DOI: |
10.1007/978-3-319-42223-7_1 |
Uncontrolled Keywords: |
T cell trafficking; Integrins; Small GTPases; Intravital imaging; Extracellular matrix; Guanine exchange factors |
URI: |
https://boris.unibe.ch/id/eprint/95413 |