The use of GRADE approach in systematic reviews of animal studies.

Wei, Dang; Tang, Kun; Wang, Qi; Estill, Janne; Yao, Liang; Wang, Xiaoqin; Chen, Yaolong; Yang, Kehu (2016). The use of GRADE approach in systematic reviews of animal studies. Journal of evidence based medicine, 9(2), pp. 98-104. Blackwell Publishing Asia 10.1111/jebm.12198

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OBJECTIVE The application of GRADE (Grading of Recommendations Assessment, Development and Evaluation) in SR of animal studies can promote the translation from bench to bedside. We aim to explore the use of GRADE in systematic reviews of animal studies. METHODS We used a theoretical analysis method to explore the use of GRADE in SR of animal studies and applied in a SR of animal studies. Meanwhile, we presented and discussed our results in two international conferences. RESULTS Five downgrade factors were considered as follows in systematic reviews of animal studies: 1) Risk of bias: the SYRCLE tool can be used for assessing the risk of bias of animal studies. 2) Indirectness: we can assess indirectness in systematic reviews of animal studies from the PICO. 3) Inconsistency: similarity of point estimates, extent of overlap of confidence intervals and statistical heterogeneity are also suitable to evaluate inconsistency of evidence from animal studies. 4) Imprecision: optimal information size (OIS) and 95% confidence intervals (CIs) are also suitable for systematic reviews of animal studies, like those of clinical trials. 5) Publication bias: we need to consider publication bias comprehensively through the qualitative and quantitative methods. CONCLUSIONS The methods about the use of GRADE in systematic review of animal studies are explicit. However, the principle about GRADE in developing the policy based on the evidence from animal studies when there is an emergency of public health. This article is protected by copyright. All rights reserved.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Estill, Janne Anton Markus


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services




Blackwell Publishing Asia




Doris Kopp Heim

Date Deposited:

08 Feb 2017 18:02

Last Modified:

02 Mar 2017 12:46

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

GRADE; animal study; systematic review




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