Feed-derived volatile basic nitrogen increases reactive oxygen species production of blood leukocytes in lactating dairy cows.

Tsunoda, Ei; Gross, Josef Johann; Kawashima, Chiho; Bruckmaier, Rupert; Kida, Katsuya; Miyamoto, Akio (2017). Feed-derived volatile basic nitrogen increases reactive oxygen species production of blood leukocytes in lactating dairy cows. Animal science journal / Nihon chikusan Gakkaihō, 88(1), pp. 125-133. Wiley 10.1111/asj.12608

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The present study investigated over 9 months the changes of fermentative quality of total mixed rations (TMR) containing grass silage (GS) as a major component, associated with changes in the volatile basic nitrogen (VBN) levels in an experimental dairy farm. Effects of VBN levels in TMR on metabolic parameters, reactive oxygen species (ROS) production by blood polymorphonuclear leukocytes (PMNs) and conception rates for dairy cows were analyzed. According to VBN levels in TMR during survey periods, three distinct phases were identified; phase A with low VBN; phase B with high VBN; and phase C with mid-VBN. Metabolic parameters in blood were all within normal range. However, during phases B and C, nitrogen metabolic indices such as blood urea nitrogen and milk urea nitrogen showed higher levels compared to those in phase A, and a simultaneous increase in ROS production by blood PMNs and the load on hepatic function in metabolic parameters was observed in the cows with a lower conception rate. This suggests that feeding TMR with elevated VBN levels due to poor fermented GS results in stimulation of ROS production by PMNs by ammonia, and negatively affects metabolism and reproductive performance in lactating dairy cow.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Physiology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Gross, Josef Johann and Bruckmaier, Rupert

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1344-3941

Publisher:

Wiley

Language:

English

Submitter:

Lorenzo Enrique Hernandez Castellano

Date Deposited:

26 Jul 2017 16:16

Last Modified:

26 Jul 2017 16:16

Publisher DOI:

10.1111/asj.12608

PubMed ID:

27145971

Uncontrolled Keywords:

dairy cow; liver function; poor fermented silage; reactive oxygen species; volatile basic nitrogen

BORIS DOI:

10.7892/boris.95855

URI:

https://boris.unibe.ch/id/eprint/95855

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