Increasing serotonin concentrations alter calcium and energy metabolism in dairy cows.

Laporta, Jimena; Moore, Spencer A E; Weaver, Samantha R; Cronick, Callyssa M; Olsen, Megan; Prichard, Austin P; Schnell, Brian P; Crenshaw, Thomas D; Peñagaricano, Francisco; Bruckmaier, Rupert; Hernandez, Laura L (2015). Increasing serotonin concentrations alter calcium and energy metabolism in dairy cows. Journal of endocrinology, 226(1), pp. 43-55. BioScientifica 10.1530/JOE-14-0693

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A 4×4 Latin square design in which varied doses (0, 0.5, 1.0, and 1.5 mg/kg) of 5-hydroxy-l-tryptophan (5-HTP, a serotonin precursor) were intravenously infused into late-lactation, non-pregnant Holstein dairy cows was used to determine the effects of serotonin on calcium and energy metabolism. Infusion periods lasted 4 days, with a 5-day washout between periods. Cows were infused at a constant rate for 1 h each day. Blood was collected pre- and 5, 10, 30, 60, 90, and 120 min post-infusion, urine was collected pre- and post-infusion, and milk was collected daily. All of the 5-HTP doses increased systemic serotonin as compared to the 0 mg/kg dose, and the 1.0 and 1.5 mg/kg doses increased circulating glucose and non-esterified fatty acids (NEFA) and decreased beta-hydroxybutyrate (βHBA) concentrations. Treatment of cows with either 1.0 or 1.5 mg/kg 5-HTP doses decreased urine calcium elimination, and the 1.5 mg/kg dose increased milk calcium concentrations. No differences were detected in the heart rates, respiration rates, or body temperatures of the cows; however, manure scores and defecation frequency were affected. Indeed, cows that received 5-HTP defecated more, and the consistency of their manure was softer. Treatment of late-lactation dairy cows with 5-HTP improved energy metabolism, decreased loss of calcium into urine, and increased calcium secretion into milk. Further research should target the effects of increasing serotonin during the transition period to determine any benefits for post-parturient calcium and glucose metabolism.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Physiology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)

UniBE Contributor:

Bruckmaier, Rupert

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

0022-0795

Publisher:

BioScientifica

Language:

English

Submitter:

Lorenzo Enrique Hernandez Castellano

Date Deposited:

20 Jul 2017 12:23

Last Modified:

20 Jul 2017 12:23

Publisher DOI:

10.1530/JOE-14-0693

PubMed ID:

26099356

Uncontrolled Keywords:

BHBA; NEFA; PTHrP; calcium; glucose; insulin; serotonin

BORIS DOI:

10.7892/boris.95879

URI:

https://boris.unibe.ch/id/eprint/95879

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