Discordant bone marrow involvement in non-Hodgkin lymphoma.

Brudno, Jennifer; Tadmor, Tamar; Pittaluga, Stefania; Nicolae, Alina; Polliack, Aaron; Dunleavy, Kieron (2016). Discordant bone marrow involvement in non-Hodgkin lymphoma. Blood, 127(8), pp. 965-970. American Society of Hematology 10.1182/blood-2015-06-651968

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A discordant lymphoma occurs where 2 distinct histologic subtypes coexist in at least 2 separate anatomic sites. Histologic discordance is most commonly observed between the bone marrow (BM) and lymph nodes (LNs), where typically aggressive lymphoma is found in a LN biopsy with indolent lymphoma in a BM biopsy. Although the diagnosis of discordance relied heavily on histopathology alone in the past, the availability of flow cytometry and molecular studies have aided the identification of this entity. The true prevalence and clinical ramifications of discordance remain controversial as available data are principally retrospective, and there is therefore little consensus to guide optimal management strategies. In this review, we examine the available literature on discordant lymphoma and its outcome, and discuss current therapeutic approaches. Future studies in discordant lymphoma should ideally focus on a large series of patients with adequate tissue samples and incorporate molecular analyses.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Nicolae, Alina

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0006-4971

Publisher:

American Society of Hematology

Language:

English

Submitter:

Ekkehard Hewer

Date Deposited:

24 May 2017 12:14

Last Modified:

25 May 2017 12:16

Publisher DOI:

10.1182/blood-2015-06-651968

PubMed ID:

26679865

BORIS DOI:

10.7892/boris.95939

URI:

https://boris.unibe.ch/id/eprint/95939

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