Prevalence and risk factors for venous thromboembolic complications in the Swiss Inflammatory Bowel Disease Cohort.

Alatri, Adriano; Schoepfer, Alain; Fournier, Nicolas; Engelberger, Rolf Peter; Safroneeva, Ekaterina; Vavricka, Stephan; Biedermann, Luc; Calanca, Luca; Mazzolai, Lucia (2016). Prevalence and risk factors for venous thromboembolic complications in the Swiss Inflammatory Bowel Disease Cohort. Scandinavian journal of gastroenterology, 51(10), pp. 1200-1205. Informa Healthcare 10.1080/00365521.2016.1185464

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OBJECTIVE

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is associated with the occurrence of venous thromboembolism (VTE) such as deep vein thrombosis (DVT) and pulmonary embolism (PE). We aimed to assess the prevalence and associated risk factors for VTE in a large national cohort of IBD patients.

MATERIAL AND METHODS

Data from patients of the Swiss IBD Cohort Study (SIBDCS) enrolled between 2006 and 2013 were analyzed.

RESULTS

A total of 2284 IBD patients were analyzed of which 1324 suffered from CD and 960 from UC. VTE prevalence was 3.9% (90/2284) overall and 3.4% (45/1324) in CD patients (whereof 2.4% suffered from DVT and 1.5% from PE) and 4.7% (45/960) in UC patients (whereof 3.2% suffered from DVT and 2.4% from PE). Median disease duration in CD patients with VTE was 12 years [IQR 8-23] compared to eight years [3-16] in CD patients without VTE (p = 0.001). Disease duration in UC patients with VTE was seven years [4-18] compared to six years [2-13] in UC patients without VTE (p = 0.051). Age at CD diagnosis ≥40 years (OR 1.851, p = 0.073) and disease duration >10 years (OR 1.771, p = 0.088) showed a trend to be associated with VTE. In UC patients, IBD-related surgery (OR 3.396, p = 0.004) and pancolitis (OR 1.927, p = 0.050) were significantly associated with VTE.

CONCLUSIONS

VTE are prevalent in CD and UC patients. Pancolitis and UC-related surgery are significantly associated with VTE in UC patients.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
UniBE Contributor:	Safroneeva, Ekaterina
Subjects:	600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services
ISSN:	0036-5521
Publisher:	Informa Healthcare
Language:	English
Submitter:	Doris Kopp Heim
Date Deposited:	16 Feb 2017 13:17
Last Modified:	05 Dec 2022 15:03
Publisher DOI:	10.1080/00365521.2016.1185464
PubMed ID:	27211077
Uncontrolled Keywords:	Crohn's disease thromboembolic complications ulcerative colitis venous thromboembolism
URI:	https://boris.unibe.ch/id/eprint/95974