Pecks, Ulrich; Rath, Werner; Bauerschlag, Dirk O; Maass, Nicolai; Orlikowsky, Thorsten; Mohaupt, Markus G; Escher, Geneviève (2017). Serum cholesterol acceptor capacity in intrauterine growth restricted fetuses. Journal of perinatal medicine, 45(7), pp. 829-835. De Gruyter 10.1515/jpm-2016-0270
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Pecks 2017 - JPM Cholesterol Efflux in IUGR.pdf - Published Version Available under License Publisher holds Copyright. Download (191kB) | Preview |
AIM
Intrauterine growth restriction (IUGR) is an independent risk factor for the development of cardiovascular diseases later in life. The mechanisms whereby slowed intrauterine growth confers vascular risk are not clearly established. In general, a disturbed cholesterol efflux has been linked to atherosclerosis. The capacity of serum to accept cholesterol has been repeatedly evaluated in clinical studies by the use of macrophage-based cholesterol efflux assays and, if disturbed, precedes atherosclerotic diseases years before the clinical diagnosis. We now hypothesized that circulating cholesterol acceptors in IUGR sera specifically interfere with cholesterol transport mechanisms leading to diminished cholesterol efflux.
METHODS
RAW264.7 cells were used to determine efflux of [3H]-cholesterol in response to [umbilical cord serum (IUGR), n=20; controls (CTRL), n=20].
RESULTS
Cholesterol efflux was lower in IUGR as compared to controls [controls: mean 7.7% fractional [3H]-cholesterol efflux, standard deviation (SD)=0.98; IUGR: mean 6.3%, SD=0.79; P<0.0001]. Values strongly correlated to HDL (ρ=0.655, P<0.0001) and apoE (ρ=0.510, P=0.0008), and mildly to apoA1 (ρ=0.3926, P=0.0122) concentrations.
CONCLUSIONS
Reduced cholesterol efflux in IUGR could account for the enhanced risk of developing cardiovascular diseases later in life.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Nephrologie / Hypertonie 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Pecks, Ulrich, Escher, Geneviève |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0300-5577 |
Publisher: |
De Gruyter |
Language: |
English |
Submitter: |
Geneviève Escher |
Date Deposited: |
15 Nov 2017 15:16 |
Last Modified: |
05 Dec 2022 15:03 |
Publisher DOI: |
10.1515/jpm-2016-0270 |
PubMed ID: |
28195552 |
BORIS DOI: |
10.7892/boris.95987 |
URI: |
https://boris.unibe.ch/id/eprint/95987 |
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