Bioimpedance-Derived Phase Angle and Mortality Among Older People.

Genton, Laurence; Norman, Kristina; Spörri, Adrian; Pichard, Claude; Karsegard, Véronique L; Herrmann, François R; Graf, Christophe E (2017). Bioimpedance-Derived Phase Angle and Mortality Among Older People. Rejuvenation Research, 20(2), pp. 118-124. Mary Ann Liebert 10.1089/rej.2016.1879

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BACKGROUND Phase angle measured by bioelectrical impedance analysis (BIA) may be a marker of health state. OBJECTIVE This historical cohort study of prospectively collected BIA measurements aims to investigate the link between phase angle and mortality in older people and evaluate whether a phase angle cutoff can be defined. DESIGN We included all adults aged ≥65 years who underwent a BIA measurement by the Nutriguard(®) device at the Geneva University Hospitals. We retrieved retrospectively the phase angle and comorbidities at the last BIA measurement and mortality until December 2012. We calculated phase angle standardized for sex, age, and body mass index (BMI), using reference values determined with the same brand of BIA device. Sex-specific and standardized phase angle were categorized into quartiles. The association of mortality with sex-specific or standardized phase angle was evaluated through univariate and multivariate Cox regression models, Kaplan-Meier curves, and receiver operating characteristic (ROC) curves. RESULTS We included 1307 (38% women) participants, among whom 628 (44% women) died. In a multivariate Cox regression model adjusted for comorbidities and setting of measurement (ambulatory vs. hospitalized), the protective effect against mortality increased progressively as the standardized phase angle quartile increased (HR 0.71 [95% CI 0.58, 0.86], 0.53 [95% CI 0.42, 0.67], and 0.32 [95% CI 0.23, 0.43]). The discriminative value of continuous standardized phase angle, assessed as the area under the ROC curve, was 0.72 (95%CI 0.70, 0.75). We could not define an acceptable phase angle cutoff for individual prediction of mortality (LK), based on sensibility and specificity values. CONCLUSIONS This study shows the association of phase angle and mortality in older patients, independent of age, sex, comorbidities, BMI categories, and setting of measurement.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Spörri, Adrian

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1549-1684

Publisher:

Mary Ann Liebert

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

16 Feb 2017 14:44

Last Modified:

24 Oct 2019 06:35

Publisher DOI:

10.1089/rej.2016.1879

PubMed ID:

27796163

Uncontrolled Keywords:

bioelectrical impedance analysis; mortality; older people; phase angle; standardized phase angle

BORIS DOI:

10.7892/boris.95988

URI:

https://boris.unibe.ch/id/eprint/95988

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