μCT-based trabecular anisotropy can be reproducibly computed from HR-pQCT scans using the triangulated bone surface

Seyed Hosseini, Hadi; Maquer, Ghislain Bernard; Zysset, Philippe (2017). μCT-based trabecular anisotropy can be reproducibly computed from HR-pQCT scans using the triangulated bone surface. Bone, 97, pp. 114-120. Elsevier 10.1016/j.bone.2017.01.016

[img] Text
Hosseini2017.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy
[img]
Preview
Text
Hosseini2017-Accepted_Manuscript.pdf - Accepted Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (1MB) | Preview

The trabecular structure can be assessed at the wrist or tibia via high-resolution peripheral quantitative computed tomography (HR-pQCT). Yet on this modality, the performance of the existing methods, evaluating trabecular anisotropy is usually overlooked, especially in terms of reproducibility. We thus proposed to compare the TRI routine used by SCANCO Medical AG (Brüttisellen, Switzerland), the classical mean intercept length (MIL), and the grey-level structure tensor (GST) to the mean surface length (MSL), a new method for evaluating a second-order fabric tensor based on the triangulation of the bone surface. The distal radius of 24 fresh-frozen human forearms was scanned three times via HR-pQCT protocols (61 μm, 82 μm nominal voxel size), dissected, and imaged via micro computed tomography (μCT) at 16 μm nominal voxel size. After registering the scans, we compared for each resolution the fabric tensors, determined by the mentioned techniques for 182 trabecular regions of interest. We then evaluated the reproducibility of the fabric information measured by HR-pQCT via precision errors. On μCT, TRI and GST were respectively the best and worst surrogates for MILμCT (MIL computed on μCT) in terms of eigenvalues and main direction of anisotropy. On HR-pQCT, however, MSL provided the best approximation of MILμCT. Surprisingly, surface-based approaches (TRI, MSL) also proved to be more precise than both MIL and GST. Our findings confirm that MSL can reproducibly estimate MILμCT, the current gold standard. MSL thus enables the direct mapping of the fabric-dependent material properties required in homogenised HR-pQCT-based finite element models.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB

UniBE Contributor:

Seyed Hosseini, Hadi; Maquer, Ghislain Bernard and Zysset, Philippe

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

8756-3282

Publisher:

Elsevier

Funders:

[104] Commission for Technology and Innovation (CTI)
[88] Gebert Rüf Foundation (GRS-079/14) (GM)

Language:

English

Submitter:

Ghislain Bernard Maquer

Date Deposited:

14 Jul 2017 15:15

Last Modified:

01 May 2018 02:30

Publisher DOI:

10.1016/j.bone.2017.01.016

Related URLs:

PubMed ID:

28109918

BORIS DOI:

10.7892/boris.96021

URI:

https://boris.unibe.ch/id/eprint/96021

Actions (login required)

Edit item Edit item
Provide Feedback