Transcriptome analysis of equine sarcoids

Semik, E.; Gurgul, A.; Ząbek, T.; Ropka-Molik, K.; Koch, Christoph; Mählmann, K.; Bugno-Poniewierska, M. (2017). Transcriptome analysis of equine sarcoids. Veterinary and comparative oncology, 15(4), pp. 1370-1381. Wiley 10.1111/vco.12279

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Equine sarcoids are the most commonly detected skin tumours in Equidae. In the present research, a comparative transcriptomic analysis was performed which aimed at looking inside a tumour biology and identification of the expression profile as a potential source of cancer specific genes useful as biomarkers. We have used Horse Gene Expression Microarray data from matched equine sarcoids and tumour-distant skin samples. In total, 901 significantly differentially expressed genes (DEGs) between lesional and healthy skin samples have been identified (fold change ≥ 2; P < 0.05). The large subset of DEGs, with decreased expression, was associated with a suppression of malignant transformation, whereas several overexpressed genes were involved in the processes associated with growth and progression of a tumour or immune system activity. Our results, as a first to date, showed comprehensive transcriptome analysis of skin tumour in horses and pinpointed significant pathways and genes related with oncogenesis processes.

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