The Hair Follicle: A Comparative Review of Canine Hair Follicle Anatomy and Physiology.

Welle, Monika Maria; Wiener, Dominique Judith (2016). The Hair Follicle: A Comparative Review of Canine Hair Follicle Anatomy and Physiology. Toxicologic pathology, 44(4), pp. 564-574. Sage Publications 10.1177/0192623316631843

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The hair follicle (HF) has a wide range of functions including thermoregulation, physical and immunological protection against external insults, sensory perception, social interactions, and camouflage. One of the most characteristic features of HFs is that they self-renew during hair cycle (HC) throughout the entire life of an individual to continuously produce new hair. HC disturbances are common in humans and comparable to some alopecic disorders in dogs. A normal HC is maintained by follicular stem cells (SCs), which are predominately found in an area known as the bulge. Due to similar morphological characteristics of the human and canine bulge area, the particularity of compound HFs in humans and dogs as well as similarities in follicular biomarker expression, the dog might be a promising model to study human HC and SC disorders. In this review, we give an overview of normal follicular anatomy, the HC, and follicular SCs and discuss the possible pathogenetic mechanisms of noninflammatory alopecia.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Welle, Monika Maria and Wiener, Dominique Judith

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1533-1601

Publisher:

Sage Publications

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

24 Jul 2017 16:05

Last Modified:

24 Jul 2017 16:05

Publisher DOI:

10.1177/0192623316631843

PubMed ID:

27000375

Uncontrolled Keywords:

alopecia; canine; follicular anatomy; follicular stem cells; hair cycle; hair follicles; pathogenesis

BORIS DOI:

10.7892/boris.96438

URI:

https://boris.unibe.ch/id/eprint/96438

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