Retrograde signaling from autophagy modulates stress responses.

Simon, Hans-Uwe; Friis, Robert; Tait, Stephen W G; Ryan, Kevin M (2017). Retrograde signaling from autophagy modulates stress responses. Science signaling, 10(468) American Association for the Advancement of Science 10.1126/scisignal.aag2791

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Macroautophagy is a process in which cytoplasmic components, including whole organelles, are degraded within lysosomes. Basally, this process is essential for homeostasis and is constitutively functional in most cells, but it can also be implemented as part of stress responses. We discuss findings showing that autophagy proteins can modulate and amplify the activities of transcription factors involved in stress responses, such as those in the p53, FOXO, MiT/TFE, Nrf2, and NFκB/Rel families. Thus, transcription factors not only amplify stress responses and autophagy but are also subject to retrograde regulation by autophagy-related proteins. Physical interactions with autophagy-related proteins, competition for activating intermediates, and "signalphagy," which is the role autophagy plays in the degradation of specific signaling proteins, together provide powerful tools for implementing negative feedback or positive feed-forward loops on the transcription factors that regulate autophagy. We present examples illustrating how this network interacts to regulate metabolic and physiologic responses.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1937-9145

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Jana Berger

Date Deposited:

28 Jul 2017 09:12

Last Modified:

28 Jul 2017 09:12

Publisher DOI:

10.1126/scisignal.aag2791

PubMed ID:

28246201

BORIS DOI:

10.7892/boris.96574

URI:

https://boris.unibe.ch/id/eprint/96574

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