Vaccines for bovine neosporosis: current status and key aspects for development.

Horcajo, P; Regidor-Cerrillo, J; Aguado Martinez, Adriana; Hemphill, Andrew; Ortega-Mora, L M (2016). Vaccines for bovine neosporosis: current status and key aspects for development. Parasite immunology, 38(12), pp. 709-723. Wiley 10.1111/pim.12342

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Bovine neosporosis is a worldwide concern due to its global distribution and great economic impact. Reproductive failure in cattle due to abortion leads to major economic losses associated with the disease. Currently, there is no treatment or vaccine available against abortion or transmission caused by Neospora caninum infection in cattle. However, vaccination is considered the best measure of control against bovine neosporosis. Several host and parasite factors can influence the dynamics of the infection in bovines. Moreover, the availability of well-defined infection models is a key factor for the evaluation of vaccine candidates. However, working with cattle is not easy due to difficult handling, facilities and costs, and therefore, 'more affordable' models could be used for screening of promising vaccines to establish proof of concept. So far, live-attenuated vaccines have shown good efficacy against exogenous transplacental transmission; however, they have relevant disadvantages and associated risks, which render inactivated or subunit vaccines the best way forward. The identification of novel potential targets and vaccines, and the application of innovative vaccine technologies in harmonized experimental animal models, will accelerate the development of an effective vaccine against bovine neosporosis.

Item Type:

Journal Article (Review Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Aguado Martinez, Adriana and Hemphill, Andrew

Subjects:

600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)

ISSN:

0141-9838

Publisher:

Wiley

Language:

English

Submitter:

Andrew Hemphill

Date Deposited:

06 Jun 2017 15:07

Last Modified:

16 Aug 2018 16:28

Publisher DOI:

10.1111/pim.12342

PubMed ID:

27314818

Uncontrolled Keywords:

animal models; bovine neosporosis; infection dynamics; vaccines

BORIS DOI:

10.7892/boris.96634

URI:

https://boris.unibe.ch/id/eprint/96634

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