Apicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamics.

De Amorim Cardoso, Rita Isabel; Soares, Helena; Hemphill, Andrew; Leitão, Alexandre (2016). Apicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamics. Parasitology, 143(8), pp. 957-970. Cambridge University Press 10.1017/S0031182016000524

Preview

Text apicomplexans_pulling_the_strings_manipulation_of_the_host_cell_cytoskeleton_dynamics.pdf - Published Version Available under License Publisher holds Copyright. Download (376kB) | Preview

Invasive stages of apicomplexan parasites require a host cell to survive, proliferate and advance to the next life cycle stage. Once invasion is achieved, apicomplexans interact closely with the host cell cytoskeleton, but in many cases the different species have evolved distinct mechanisms and pathways to modulate the structural organization of cytoskeletal filaments. The host cell cytoskeleton is a complex network, largely, but not exclusively, composed of microtubules, actin microfilaments and intermediate filaments, all of which are modulated by associated proteins, and it is involved in diverse functions including maintenance of cell morphology and mechanical support, migration, signal transduction, nutrient uptake, membrane and organelle trafficking and cell division. The ability of apicomplexans to modulate the cytoskeleton to their own advantage is clearly beneficial. We here review different aspects of the interactions of apicomplexans with the three main cytoskeletal filament types, provide information on the currently known parasite effector proteins and respective host cell targets involved, and how these interactions modulate the host cell physiology. Some of these findings could provide novel targets that could be exploited for the development of preventive and/or therapeutic strategies.

Interest & Impact

Downloads

70 since deposited on 24 Jul 2017
42 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item