Apicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamics.

De Amorim Cardoso, Rita Isabel; Soares, Helena; Hemphill, Andrew; Leitão, Alexandre (2016). Apicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamics. Parasitology, 143(8), pp. 957-970. Cambridge University Press 10.1017/S0031182016000524

[img] Text
apicomplexans_pulling_the_strings_manipulation_of_the_host_cell_cytoskeleton_dynamics.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (376kB) | Request a copy

Invasive stages of apicomplexan parasites require a host cell to survive, proliferate and advance to the next life cycle stage. Once invasion is achieved, apicomplexans interact closely with the host cell cytoskeleton, but in many cases the different species have evolved distinct mechanisms and pathways to modulate the structural organization of cytoskeletal filaments. The host cell cytoskeleton is a complex network, largely, but not exclusively, composed of microtubules, actin microfilaments and intermediate filaments, all of which are modulated by associated proteins, and it is involved in diverse functions including maintenance of cell morphology and mechanical support, migration, signal transduction, nutrient uptake, membrane and organelle trafficking and cell division. The ability of apicomplexans to modulate the cytoskeleton to their own advantage is clearly beneficial. We here review different aspects of the interactions of apicomplexans with the three main cytoskeletal filament types, provide information on the currently known parasite effector proteins and respective host cell targets involved, and how these interactions modulate the host cell physiology. Some of these findings could provide novel targets that could be exploited for the development of preventive and/or therapeutic strategies.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

De Amorim Cardoso, Rita Isabel and Hemphill, Andrew

Subjects:

600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology

ISSN:

0031-1820

Publisher:

Cambridge University Press

Language:

English

Submitter:

Andrew Hemphill

Date Deposited:

24 Jul 2017 13:00

Last Modified:

16 Aug 2018 16:14

Publisher DOI:

10.1017/S0031182016000524

PubMed ID:

27041483

Uncontrolled Keywords:

Apicomplexa; actin; host–parasite interaction; intermediate filaments; microtubules

BORIS DOI:

10.7892/boris.96636

URI:

https://boris.unibe.ch/id/eprint/96636

Actions (login required)

Edit item Edit item
Provide Feedback