Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer.

Annunziato, Stefano; Barazas, Marco; Rottenberg, Sven; Jonkers, Jos (2016). Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer. Cold Spring Harbor Symposia on Quantitative Biology, 81, pp. 141-150. Biological Laboratory 10.1101/sqb.2016.81.030924

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The cancer genomics revolution has rapidly expanded the inventory of somatic mutations characterizing human malignancies, highlighting a previously underappreciated extent of molecular variability between and within patients. Also in breast cancer, the most commonly diagnosed malignancy in women, this heterogeneity complicates the understanding of the stepwise sequence of pathogenic events and the design of effective and long-lasting target therapies. To disentangle this complexity and pinpoint which molecular perturbations are crucial to hijack the cellular machinery and lead to tumorigenesis and drug resistance, functional studies are needed in model systems that faithfully and comprehensively recapitulate all the salient aspects of their cognate human counterparts. Mouse models of breast cancer have been instrumental for the study of tumor initiation and drug response but also involve cost and time limitations that represent serious bottlenecks in translational research. To keep pace with the overwhelming amount of hypotheses that warrant in vivo testing, continuous refinement of current breast cancer models and implementation of new technologies is crucial. In this review, we summarize the current state of the art in modeling human breast cancer in mice, and we put forward our vision for future developments.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Rottenberg, Sven

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0091-7451

Publisher:

Biological Laboratory

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

01 Jun 2017 12:55

Last Modified:

15 Jun 2017 01:31

Publisher DOI:

10.1101/sqb.2016.81.030924

PubMed ID:

27815543

BORIS DOI:

10.7892/boris.96715

URI:

https://boris.unibe.ch/id/eprint/96715

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