In vivo demonstration of reflection artifact reduction in photoacoustic imaging using synthetic aperture photoacoustic-guided focused ultrasound (PAFUSion)

Singh, Mithun Kuniyil Ajith; Jaeger, Michael; Frenz, Martin; Steenbergen, Wiendelt (2016). In vivo demonstration of reflection artifact reduction in photoacoustic imaging using synthetic aperture photoacoustic-guided focused ultrasound (PAFUSion). Biomedical optics express, 7(8), pp. 2955-2972. Optical Society of America 10.1364/BOE.7.002955

[img] Text
2955.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (4MB) | Request a copy

Reflection artifacts caused by acoustic inhomogeneities are a critical problem in epi-mode biomedical photoacoustic imaging. High light fluence beneath the probe results in photoacoustic transients, which propagate into the tissue and reflect back from echogenic structures. These reflection artifacts cause problems in image interpretation and significantly impact the contrast and imaging depth. We recently proposed a method called PAFUSion (Photoacoustic-guided focused ultrasound) to identify such reflection artifacts in photoacoustic imaging. In its initial version, PAFUSion mimics the inward-travelling wavefield from small blood vessel-like PA sources by applying ultrasound pulses focused towards these sources, and thus provides a way to identify the resulting reflection artifacts. In this work, we demonstrate reduction of reflection artifacts in phantoms and in vivo measurements on human volunteers. In view of the spatially distributed PA sources that are found in clinical applications, we implemented an improved version of PAFUSion where photoacoustic signals are backpropagated to imitate the inward travelling wavefield and thus the reflection artifacts. The backpropagation is performed in a synthetic way based on the pulse-echo acquisitions after transmission on each single element of the transducer array. The results provide a direct confirmation that reflection artifacts are prominent in clinical epi-photoacoustic imaging, and that PAFUSion can strongly reduce these artifacts to improve deep-tissue photoacoustic imaging.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Institute of Applied Physics
08 Faculty of Science > Institute of Applied Physics > Biomedical Photonics

UniBE Contributor:

Jaeger, Michael and Frenz, Martin

Subjects:

600 Technology > 620 Engineering
500 Science
500 Science > 530 Physics

ISSN:

2156-7085

Publisher:

Optical Society of America

Language:

English

Submitter:

Simone Corry

Date Deposited:

13 Jul 2017 08:23

Last Modified:

13 Jul 2017 08:23

Publisher DOI:

10.1364/BOE.7.002955

BORIS DOI:

10.7892/boris.96958

URI:

https://boris.unibe.ch/id/eprint/96958

Actions (login required)

Edit item Edit item
Provide Feedback